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Articles by Wouter Scheper
Learning the language of T cell receptors through large-scale screening
Get full text access Log in, subscribe or purchase for full access. References 1. Davis, M.M. ∙ Bjorkman, P.J. T-cell antigen receptor genes and T-cell recognition Nature. 1988; 334:395-402 2. Birnbaum, M.E. ∙ Dong, S. ∙ Garcia, K.C. Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function Immunol. Rev. 2012; 250:82-101 3. Hu, Z. ∙ Anandappa, A.J. ∙ Sun, J. ...
Mapping the landscape of T cell-recognized neoantigens in cancer patients - Genes & Immunity
Immunotherapies for cancer that seek to leverage the anti-tumor reactivity of T cells, such as immune checkpoint inhibition, have yielded remarkable clinical effects in a proportion of cancer patients.
STAPLER: Efficient learning of TCR-peptide specificity prediction from full-length TCR-peptide data
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Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
1. Ribas, A. & Wolchok, J. D. Cancer immunotherapy using checkpoint blockade. Science 359, 1350–1355 (2018). 2. Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960–1964 (2006). 3. Zhang, L. et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203–213 (2003). 4. Sharma, P. & Allison, J. P. The future of immune checkpoint therapy. Science 348, 56–61 (2015). 5. Tumeh, P. C. et al.
RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor
Identification of Genetic Loci Associated with Vγ9Vδ2 TCR-Mediated Target Cell Recognition by SNP-Associated Computational Pathway Hunt Including shRNA Evaluation The Intracellular Distribution of RhoB in Cancer Stem Cells Marks Susceptibility for Vγ9Vδ2 TCR-Mediated Recognition RhoB Interacts with BTN3A1 Homodimers in Cancer Cells Recognized by Vγ9Vδ2 TCRs Phosphoantigen Accumulation Associates with Conformational Changes of BTN3A1 Dimers Given the strong requirement for RhoB activity in the...
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