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Xandra Nuqui

As seen in: Nature, BioRxiv
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Articles

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens - Nature Communications

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By Xandra Nuqui, Lorenzo Casalino, Ling Zhou, Albert Wang, Alexandra L. Tse, Surl-Hee Ahn, Jason S. McLellan
| Nature Verified
Abstract The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, S2’s usage as an alternative vaccine strategy is hampered by its general instability.
Open in Who Shared Issue with article?

Simulation-Driven Design of Stabilized SARS-CoV-2 Spike S2 Immunogens

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By Xandra Nuqui, Lorenzo Casalino, Ling Zhou, Mohamed Shehata
| BioRxiv
Abstract The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, the usage of S2 as an alternative vaccine strategy is hampered by its general instability.
Open in Who Shared Issue with article?

Simulation-Driven Design of Stabilized SARS-CoV-2 Spike S2 Immunogens

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By Lorenzo Casalino, Ling Zhou, Mohamed Shehata, Xandra Nuqui
| BioRxiv
Abstract The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodominant S1 subunit. S2, in contrast, is the most evolutionarily conserved region of the spike and can elicit broadly neutralizing and protective antibodies. Yet, the usage of S2 as an alternative vaccine strategy is hampered by its general instability.
Open in Who Shared Issue with article?
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