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Xavier Duportet on Muck Rack

Xavier Duportet

Paris
As seen in: Nature
Genome Architect - CEO EligoBio & President Hello Tomorrow - MIT TR35 / WEF Tech Pioneer & Young Global Leader / Forbes 30 Under 30
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Articles

In situ targeted base editing of bacteria in the mouse gut - Nature

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By Jan Havránek, Simone Pignotti, Jesus Fernandez-Rodriguez, Xavier Duportet
| Nature Verified
Abstract Microbiome research is now demonstrating a growing number of bacterial strains and genes that affect our health1. Although CRISPR-derived tools have shown great success in editing disease-driving genes in human cells2, we currently lack the tools to achieve comparable success for bacterial targets in situ. Here we engineer a phage-derived particle to deliver a base editor and modify Escherichia coli colonizing the mouse gut. Editing of a β-lactamase gene in a model E.
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