Xenia Lojewski

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Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

Jan 23, 2018 |

By Arun Pal, Marcel Naumann, Anand Goswami, Xenia Lojewski

| Nature

We included cell lines carrying “benign” (R521C, L) and “malign” (R495QfsX527, P525L) FUS mutations and systematically compared them to three control iPSC lines from healthy volunteers and to isogenic lines (Table 1).

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Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

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