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Articles by Xia He
Author Correction: Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial
Correction to: Nature Medicine https://doi.org/10.1038/s41591-021-01444-0, published online 2 August 2021. In the version of this article initially published, in the Results section, there was an error in the number and percentage of patients who continued maintenance treatment after chemotherapy, which should have read 233 (80.6%) rather than 231 (79.9%). The corresponding total in the legend to Extended Data Fig. 1 should have read 233 rather than 231. In Fig.
Prediction of the unconfined compressive strength of cemented mine backfill from multi-source data using out-of-fold stacking and blending
Abstract Accurate prediction of the unconfined compressive strength (UCS) of cemented mine backfill is essential for intelligent mine backfill design. This study develops Out-of-Fold Stacking and Blending (OOF-StackBlend), an ensemble that uses support vector regression (SVR) and extreme gradient boosting (XGBoost) as base learners for 1,009 heterogeneous records spanning mix proportions, curing conditions, chemical composition and etc.
HSP90AA1 induces M2 macrophage polarization via stabilizing ITGB1 and promoting CCL2 secretion in nasopharyngeal carcinoma
Abstract Nasopharyngeal carcinoma (NPC) presents a major treatment challenge, largely due to immunotherapy resistance. The molecular mechanisms that drive the remodeling of the immunosuppressive tumor microenvironment (TME) in NPC are still not well understood. This study explored how heat shock protein 90 alpha family class A member 1 (HSP90AA1) regulated the NPC immune microenvironment. A total of 54 NPC patients receiving first-line immunotherapy were analyzed by immunohistochemistry (IHC).
Sequential antibody induction for immune tolerance in clinical organ transplantation: a feasibility review of immunosuppressant withdrawal protocols
Abstract Long-term immunosuppressant use after solid organ transplantation causes serious complications, including chronic rejection, infection, malignancy, and metabolic disorders, which has motivated the clinical pursuit of immune tolerance induction.
C-MET tyrosine kinase receptor: mechanisms, clinical applications and future perspectives in cancer therapy
Abstract The high incidence and mortality rates of tumors have resulted in significant social and economic burdens, posing a major global threat to human life and societal development. In recent years, molecular targeted therapy for tumors has become a research hotspot.
How endorser attributes influence conservation communication
INTRODUCTION Celebrity participation in environmental conservation has increased and expanded in recent decades (Abidin et al., 2020; Olmedo et al., 2020), and celebrities are playing an increasingly important role in how people understand and engage with environmental protection (Abidin et al., 2020). The participation of celebrities in environmental activities can attract the public's attention.
Case Report: Low-dose radiotherapy as part of multimodal salvage therapy for immunotherapy-resistant SMARCA4-deficient non‐small cell lung cancer
Abstract SMARCA4-deficient non-small cell lung cancer (SD-NSCLC) is a highly aggressive molecular subtype. This malignancy is often diagnosed at an advanced stage, carrying a dismal prognosis and also demonstrating poor responsiveness to traditional treatment. Beyond its primary site, the disease can exhibit unusual metastatic patterns such as metastasis to oral soft tissues.
Target-prioritized IMRT for nasopharyngeal carcinoma with tumor proximity to the spinal cord: clinical feasibility and long-term outcomes
ORIGINAL RESEARCH article Front. Oncol., 06 July 2026 Sec. Radiation Oncology Volume 16 - 2026 | https://doi.org/10.3389/fonc.2026.1878456 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
DTI-ALPS index and cognitive impairment in cerebral small vessel disease: a systematic review and meta-analysis
Abstract Objective: The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is a non-invasive diffusion tensor imaging-based metric proposed to reflect glymphatic processes. This meta-analysis aimed to evaluate the association of the DTI-ALPS index with cerebral small vessel disease (CSVD) and CSVD-associated cognitive impairment.
Emerging immunotherapeutic strategies for malignant serous effusions: current evidence and future directions
1 Introduction Based on the International Agency for Research on Cancer (IARC) data in 2022, approximately 20 million new cancer cases were diagnosed worldwide, resulting in about 9.7 million cancer-related deaths (1, 2). Metastasis remains the leading cause of cancer-related deaths (3).
ONO-Cobalt Catalyzed Reduction of Sulfoxides to Sulfides with Poly(methylhydrosiloxane) as the Deoxygenation Reagent
Herein the cobalt-catalyzed reduction of sulfoxides to sulfides with a well-defined tridentate tetrahydroquinolin-8-one-2-carboxamide (ONO)–cobalt complex as the precatalyst is reported. Inexpensive poly(methylhydrosiloxane) (PMHS) is used as the reductant. This newly developed catalytic system is applied successfully to a broad range of substrates, including diaryl, aryl alkyl, and dialkyl sulfoxides as well as cyclic sulfoxides, and accordingly delivered diverse sulfides in high yields.
Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy | Cell Death & Differentiation
Abstract T cell immunoglobulin and ITIM domain (TIGIT) is one of the most important immune checkpoints expressed on lymphocytes, and poliovirus receptor (PVR, also CD155) serves as the most crucial ligand for TIGIT, harboring an important function in cancer cells and influencing the tumor microenvironment (TME). While it’s well-established that TIGIT blockade could reverse immunosuppression, the question of whether direct inhibition of PVR yields comparable results remains to be fully elucidated.
Exploring the Roles of Anaesthetists in Positioning the Surgical Patient
Dear Editor, Patient positioning in surgery is a critical aspect of perioperative care that significantly impacts patient safety and surgical outcomes (O'Connor and Radcliffe 2021). The process involves placing the patient in a position that provides the surgeon with optimal access to the surgical site while minimising the risk of injury to the patient.
Long-term follow-up of protective effects on salivary and swallowing structures and improvement of late xerostomia and dysphagia by level IIb optimisation in clinical target volume of nasopharyngeal carcinoma | BMC Cancer | Full Text
This retrospective study included 415 patients newly diagnosed with NPC at our institution between December 2014 and October 2018. The inclusion criteria were: (1) pathologically confirmed nasopharyngeal squamous carcinoma (2), no prior treatment (3), no evidence of distant metastases at primary treatment (4), completion of the entire course of IMRT, and (5) no previous radiotherapy or head and neck surgery. The study was approved by the Ethics Committee of the Jiangsu Cancer Hospital.
Bifidobacterium pseudocatenulatum NCU-08 ameliorated senescence via modulation of the AMPK/Sirt1 signaling pathway and gut microbiota in mice
Bifidobacterium pseudocatenulatum NCU-08 ameliorated senescence via modulation of the AMPK/Sirt1 signaling pathway and gut microbiota in mice† Aging is a degenerative disease in which organisms and neurological functions decline. Emerging research has underscored the vital role of the gut microbiota in age-related processes. However, the identification of aging-associated core microbiota remains limited. In this investigation, we isolated a strain of B.
Clinical efficacy of montelukast sodium combination therapy for cough variant asthma in children: A meta‐analysis
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description ppul26960-sup-0001-Supplementary_Figure_1.tif1.3 MB Supporting Information. ppul26960-sup-0002-Supplementary_Figure_2.tif1.4 MB Suporting Information. ppul26960-sup-0003-Supplementary_Figure_3.tif1.2 MB Supporting Information. ppul26960-sup-0004-Supplementary_Table_1.doc56 KB Supporting information. ppul26960-sup-0005-Supplementary_table_2.doc19.5 KB Supporting information.
A Nitinol-Embedded Wearable Soft Robotic Gripper for Deep-Sea Manipulation: A Wearable Device for Deep-Sea Delicate Operation
Loading [a11y]/accessibility-menu.js A Nitinol-Embedded Wearable Soft Robotic Gripper for Deep-Sea Manipulation: A Wearable Device for Deep-Sea Delicate Operation | IEEE Journals & Magazine | IEEE Xplore Skip to Main Content Abstract:Soft robotic gripper systems that can safely and nondestructively collect biological and artifact samples and perform deep-sea manipulation tasks are essential for deep-s...View more Metadata Abstract: Soft robotic gripper systems that can safely and...
The Molecular Mechanism of Relatively Low-Temperature-Induced Broccoli Flower Bud Differentiation Revealed by Transcriptomic Profiling
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Preparation Optimization of Enhanced Poplar Wood by Organic-Inorganic Hybrid Treatment via Response Surface Methodology
1. Introduction Fast-growing wood as a natural resource could be used as building materials with the advantages of short growing cycles and high storage capacity [1,2]. It can be an alternative to natural forest wood and is suitable for large-scale logging and applications. However, due to its poor mechanical and physical properties, fast-growing wood could not be used widely, and its service life is short. Various methods have been applied to enhance the performance of fast-growing wood [3,4].
Correction: Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition - BMC Cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
Frontiers | Interactions between vaginal local cytokine IL-2 and high-risk human papillomavirus infection with cervical intraepithelial neoplasia in a Chinese population-based study
Ruoxi Zhu1†, Wenhao Wang1†, Aiming Yang2,3†, Weihong Zhao1, Wei Wang1, Zhilian Wang1, Jintao Wang4, Yongli Hou1, Xiaoqiang Su1, Lili Zhang1, Bo Feng1, Jing Yang1, Zhe Wang1, Xiaofen Niu1, Weiguo Lv5, Zhican Qu1 and Min Hao1* 1Departments of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, China 3Hong Kong Institute of...
High red cell distribution width-to-platelet ratio indicates adverse outcomes for hepatitis B virus-associated decompensated cirrhosis
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Immune Response to Seasonal Influenza Vaccination in Multiple Sclerosis Patients Receiving Cladribine
Open AccessArticle by 1,*,†, 2,†, 3,4, 3,4, 3,4, 3,4, 1, 1, 1, 3,4, 3,4, 3,4, 3,4,†, 1,† and 3,4,† 1 Department of Neurology, HeinrichHeine University Düsseldorf, 40225 Duesseldorf, Germany 2 Department of Neurology, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, 35392 Giessen, Germany 3 Department of Neurology and Center for Translational Neuro and Behavioral Science, University Medicine Essen, 45127 Essen, Germany 4 Center for Translational Neuro and Behavioral...
Excellent energy storage properties and superior stability achieved in lead-free ceramics via spatial sandwich structure design strategy
Excellent energy storage properties and superior stability achieved in lead-free ceramics via spatial sandwich structure design strategy Lead-free ceramics play a vital role in the context of sustainable development for energy storage applications due to their high power density, excellent high temperature resistance and nontoxicity.
Sufficiently optimized energy storage properties of the antiferroelectric ceramics by modulating the phase structure via constructing a novel binary composite
Sufficiently optimized energy storage properties of the antiferroelectric ceramics by modulating the phase structure via constructing a novel binary composite A novel binary composite of (Pb, La)(Zr, Sn)O3-AgNbO3 (PLZS-AN) was designed and constructed to optimize the comprehensive energy storage properties. With little addition of AN, some superior energy storage performances especially in the actual charge-discharge process arose.
Tetrahedral DNA Nanostructure-decorated Electrochemical Platform for Simple and Ultrasensitive EGFR Genotyping of Plasma ctDNA
Tetrahedral DNA Nanostructure-decorated Electrochemical Platform for Simple and Ultrasensitive EGFR Genotyping of Plasma ctDNA Genotyping of the epidermal growth factor receptor (EGFR) mutation status is of great importance in the screening of appropriate advanced non-small cell lung carcinoma (NSCLC) patients to receive superior tyrosine kinase inhibitors (TKIs) therapy.
Highly Mesoporous C Nanofibers with Graphitized Pore Walls Fabricated via ZnCo2O4-Induced Activating-Catalyzed-Graphitization for Long-Lifespan Lithium-Ion Batteries - Journal of Materials Chemistry A (RSC Publishing)
Transition metals (TMs) e.g. Fe, Co, and Ni, are normally unsuitable for the fabrication of highly porous C materials with graphitized C layers since in-situ formed carbides on the surface of the TMs impede their catalyzed-graphitization effect.
Differential Decay of Wastewater Bacteria and Change of Microbial Communities in Beach Sand and Seawater Microcosms
Laboratory microcosm experiments were conducted to determine the decay kinetics of wastewater bacteria and the change of microbial communities in beach sand and seawater. Cultivation-based methods showed that common fecal indicator bacteria (FIBs; Escherichia coli, enterococci, and Clostridium perfringens) exhibited biphasic decay patterns in all microcosms. Enterococci and C. perfringens, but not E. coli, showed significantly smaller decay rates in beach sand than in seawater.
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