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Articles by Xia Ling
Conditional genetic manipulation systems in mosquitoes: Progress, Challenges, and perspectives
Introduction Mosquitoes are major vectors of multiple infectious diseases, including malaria, dengue fever, and chikungunya, causing hundreds of millions of infections each year and posing persistent threats to global public health and socioeconomic development (Bhatt et al., 2013; Weaver & Lecuit, 2015; World Health Organization, 2025). Interrupting the transmission of mosquito-borne diseases has long been a major goal of global disease prevention and control efforts (Ferguson, 2018).
Efficient expansion of XCR1 + CD141 + cDC1 cells from human PBMCs: a promising strategy for DC-based vaccine
Abstract Introduction: Dendritic cells (DCs) are pivotal orchestrators of immune activation, serving as professional antigen-presenting cells that bridge innate and adaptive immunity. Among them, conventional type 1 dendritic cells (cDC1s) play a critical role in initiating cytotoxic T-cell responses and anti-tumor immunity. Despite their therapeutic promise, the clinical translation of cDC1-based vaccines has been limited by challenges in large-scale in vitro generation.
Unlocking Phthalonitrile-Based Type I Photosensitizer Through D-A Modulation to Promote Electron Transfer
Xia Ling and Zhiyao Li contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description adma74143-sup-0001-SuppMat.docx15.6 MB Supporting File: adma74143-sup-0001-SuppMat.docx. References 1, “Cancer Revoked: Oncogenes as Therapeutic Targets,” Nature Reviews Cancer 3, no.
Unlocking Phthalonitrile-Based Type I Photosensitizer Through D-A Modulation to Promote Electron Transfer
Xia Ling and Zhiyao Li contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description adma74143-sup-0001-SuppMat.docx15.6 MB Supporting File: adma74143-sup-0001-SuppMat.docx. References 1, “Cancer Revoked: Oncogenes as Therapeutic Targets,” Nature Reviews Cancer 3, no.
Progress in the study of structure, stability and functional activity of pyranoanthocyanins
Food and Fermentation Industries ›› 2026, Vol. 52 ›› Issue (5) : 403-413. DOI: 10.13995/j.cnki.11-1802/ts.043555 Progress in the study of structure, stability and functional activity of pyranoanthocyanins {{javascript:window.custom_author_en_index=0;}} {{article.zuoZhe_EN}} Author information History Download Citations {{article.zuoZheEn_L}}. {{article.title_en}}[J].
A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy
1 Introduction Photodynamic therapy (PDT) is a promising and precise cancer treatment modality known for its high spatiotemporal selectivity and minimal invasiveness.[1] PDT involves photochemical reactions between PSs and tissue-endogenous oxygen under appropriate light excitation, generating cytotoxic ROS that effectively kill cancer cells.[2] Traditional PSs are predominantly Type II agents that produce singlet oxygen (1O2) via energy transfer with heavy reliance on oxygen, which limits...
Progress in the study of structure, stability and hypoglycemic effect of acylated anthocyanins
在这里添加一些文本 RIS (ProCite, Reference Manager) BibTeX Progress in the study of structure, stability and hypoglycemic effect of acylated anthocyanins XIA Ling, CHEN Xiaolan, WANG Zichao, WANG Huichun, ZHANG Wenjian Food and Fermentation Industries ›› 2025, Vol. 51 ›› Issue (15) : 374-383. Food and Fermentation Industries ›› 2025, Vol. 51 ›› Issue (15) : 374-383.
Increased versatility and convenience: Advances and strategy optimization of Receptor‐Mediated Ovary Transduction of Cargo‐mediated genetic modification in insects
Introduction Insects represent the most diverse group of animals on Earth, making them an excellent material for studying species diversity and differentiation, the evolution of adaptive traits, metamorphosis, and body pattern development, among others (Scudder, 2009; Truman, 2019; Tihelka et al., 2021).
LAMC2 通过PI3K/ Akt 信号通路调控胃癌细胞增殖的研究
Abstract: Objective To investigate the effect of laminin subunit γ2(LAMC2) on the proliferation of gastric cancer cells through the PI3K/ Akt pathway. Methods Differentially expressed genes related to gastric cancer cell proliferation were analyzed in the cancer genome atlas and gene expression omnibus databases. The candidate gene LAMC2 was identified in accordance with the multiple of differential.
High‐efficiency gene editing in Anopheles sinensis using ReMOT control
Table S1 Survival rate and red fluorescence rate statistics of Anopheles sinensis after injection of P2C-DsRed, DsRed fusion proteins (at 20 h post-blood feeding [PBF]). Table S2 The number of laid eggs and the hatching rate after injection of a mixture of different concentrations of saponin into female Anopheles sinensis (at 20 h post-blood feeding [PBF]).
High-efficiency gene editing in Anopheles sinensis using ReMOT control
Abstract CRISPR/Cas9-mediated gene editing provides an effective method for deciphering the molecular mechanisms underlying mosquito development and mosquito-borne disease transmission, as well as for exploring genetic control strategies. However, delivering the Cas9 ribonucleoprotein complex by embryo injection to produce genetic modifications is challenging, is mostly confined to model mosquitoes and specialized laboratories, and has low editing efficiency.
The Coordination of Environmental Protection and Female Discrimination Based on the Concept of Affirmative Action
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Accelerating Sample Preparation for the Analysis of Complex Samples
Sample preparation (that is, separation and enrichment) is a critical step in complex sample analysis that affects the sensitivity, selectivity, speed, and accuracy of analytical results, especially in rapid analysis. From chaos to order, the entropy reduction procedure of sample preparation cannot happen spontaneously.
Dual detection of bioaccumulated Hg2+ based on luminescent bacteria and aggregation-induced emission
Dual detection of bioaccumulated Hg2+ based on luminescent bacteria and aggregation-induced emission Letao Huang,ab Shiwu Li,b Xia Ling,b Jun Zhang,c Anjun Qin,b Jian Zhuang,de Meng Gao*f and Ben Zhong Tang*bc Author affiliations * Corresponding authors a School of Medicine, South China University of Technology, Guangzhou 510006, China b State Key Laboratory of Luminescent Materials and Devices, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou 510640,...
In situ generation of photoactivatable aggregation-induced emission probe for organelle-specific imaging
Photoactivatable fluorescent probes are ideal tools for organelle study with significant advantage of high spatiotemporal resolution. However, conventional photo-caged fluorophores for organelle-specific imaging suffer from several drawbacks, such as aggregation-caused quenching (ACQ), instability under ambient light, low photoactivation efficiency, and toxic photo-cleavage byproducts.
Photoactivatable aggregation-induced emission probes for lipid droplets-specific live cell imaging
Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools for investigation of their biological functions through precisely spatial and temporal control. Ideal photoactivatable probes for LDs imaging require high concentration accumulation of fluorophores in LDs, simple synthetic procedures, and excellent photoactivation efficiency.
Photoactivatable aggregation-induced emission probes for lipid droplets-specific live cell imaging
Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools for investigating their biological functions through precise spatial and temporal control. Ideal photoactivatable probes for LDs imaging require high concentration accumulation of fluorophores in LDs, simple synthetic procedures, and excellent photoactivation efficiency. However, it is difficult to overcome these challenges by conventional fluorophores due to aggregation-caused quenching (ACQ).
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