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Articles by Xia Sheng
Stabilizing Ru Sites via Lattice Oxygen Locking of Nb-Ru/RuO 2 to Break the Activity–Stability Trade-Off for Acidic Oxygen Evolution
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adma75487-sup-0001-SuppMat.pdf6.2 MB Supporting File: adma75487-sup-0001-SuppMat.pdf.
Evaluating generative models for structure-based drug discovery from de novo design to lead optimization
Abstract Advances in protein structure prediction have created opportunities for structure-based drug design, yet translating structural knowledge into actionable small-molecule ligands remains difficult. Existing benchmarks often use simplified datasets and computational surrogates that poorly capture the heterogeneity and constraints of real-world drug discovery.
Accelerating hybrid XOR–CNF Boolean satisfiability problems natively with in-memory computing - Nature Communications
Abstract The Boolean satisfiability (SAT) problem is a computationally challenging decision problem central to many industrial applications. For SAT problems in cryptanalysis, circuit design, and telecommunication, solutions can often be found more efficiently by representing them with a combination of exclusive OR (XOR) and conjunctive normal form (CNF) clauses.
A grading system of intratumoral tertiary lymphoid structure for combi
Introduction Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) represents a rare tumor entity, accounting for 0.4–14.2% of primary liver cancers,1 and demonstrates poorer prognosis compared to hepatocellular carcinoma (HCC)2 and intrahepatic cholangiocarcinoma (iCCA).3 Surgical resection and liver transplantation remain the only methods proven to prolong survival for patients with cHCC-CCA.4 To date, cHCC-CCA is predominantly evaluated under the pathological diagnostic paradigm of iCCA,...
Acceptance Scale for Traditional Chinese Medicine Techniques in Cancer
Back to Journals » Patient Preference and Adherence » Volume 19 Authors Yang L , Sheng X, Lin J, Wang W, Wu X, Lin R , Liu A, Liu L Received 30 June 2025 Accepted for publication 23 October 2025 Published 7 November 2025 Volume 2025:19 Pages 3509—3525 DOI https://doi.org/10.2147/PPA.S550541 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Ramón Morillo-Verdugo Liu Yang,1,* Xia Sheng,2,* Jiayi Lin,1 Weina...
3D‐Printed Sulfonated Polyetheretherketone Porous Scaffold Modified by Bioactive Glass for Bone Repair
Supporting Information Filename Description bit70000-sup-0001-supplementary_revised.docx1 MB Supporting Information. References , , , , and . 2015. “Nanoplex-Mediated Co-Delivery of Fibroblast Growth Factor and Bone Morphogenetic Protein Genes Promotes Osteogenesis in Human Adipocyte-Derived Mesenchymal Stem Cells.” Molecular Pharmaceutics 12, no. 8: 3032–3042. , , , and . 2021.
Advancing Ligand Binding Affinity Prediction with Cartesian Tensor-Based Deep Learning
Abstract We present PBCNet2.0, a cartesian tensor-based Siamese Neural Network for protein-ligand relative binding affinity prediction. Trained on 8.6 million complex pairs, PBCNet2.0 achieves zero-shot performance comparable to computationally intensive physics-based simulations. Our prioritization experiments show that PBCNet2.0 speeds up binding affinity optimization by 718% while reducing resource use by 41%.
Efficacy of Astragalus Membranaceus (Huang Qi) for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
Introduction According to the American Cancer Society in 2020, the global incidence of cancer is currently increasing, but the cancer mortality rate shows a continuous decline1 and the number of cancer survivors is steadily increasing.
Hydrophobicity Promoted Efficient Hydroxyl Radical Generation in Visible‐Light‐Driven Photocatalytic Oxidation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202310128-sup-0001-SuppMat.pdf1.4 MB Supporting Information References 1, , , , , , Nature 2008, 452, 301. 2, , , Nat. Sustain. 2019, 2, 429. 3, , , , , , Adv. Mater. 2017, 29, 1605361. 4, , , , Chem. Rev. 1995, 95, 69. 5, , , , , Science 2001, 293, 269. 6, , , , J. Phys. D 2006, 39, 2361. 7, , , , , , , Inorg. Chem. 2013, 52, 3884. 8, , , , , , , , , , Nat. Mater. 2015, 14, 505. 9, , , Surf. Sci. Rep.
Wound incidence and outcomes in atrial fibrillation: Comparing catheter ablation and anti‐arrhythmic drug therapy
1 INTRODUCTION Atrial fibrillation (AF), which is the prevailing cardiac arrhythmia, poses substantial public health dilemma owing to its correlation with heightened rates of illness and death.1, 2 AF, which is distinguished by tachycardia and frequently an accelerated heart rate, impacts the substantial number of individuals across the world, resulting in increased susceptibility to stroke, heart failure and various other complications associated with the heart.3, 4 Present approaches to...
Electrochemical Biosensor for Protein Concentration Monitoring Using Natural Wood Evaporation for Power Generation
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
MVI for patients with HCC undergoing liver resection
Back to Journals » Journal of Hepatocellular Carcinoma » Volume 11 Authors Wang H , Chen JJ, Yin SY, Sheng X, Wang HX, Lau WY, Dong H, Cong WM Received 1 November 2023 Accepted for publication 15 January 2024 Published 24 January 2024 Volume 2024:11 Pages 191—206 DOI https://doi.org/10.2147/JHC.S447731 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Mohamed Shaker Han Wang,1,* Jun-Jie Chen,2,* Shu-Yi...
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC - npj Breast Cancer
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive type of breast cancer with a poor prognosis and a high recurrence rate. Chemotherapy is still the mainstay of treatment for cancer patients without a genetic BRCA mutation, despite the approval of Olaparib, an inhibitor of the poly (ADP-ribose) polymerase (PARP) enzyme. Tripartite motif containing-21 (TRIM21) is one of the TRIM family members that has been investigated in various types of cancer.
TIR related indexes and diabetic vascular complications
Back to Journals » Diabetes, Metabolic Syndrome and Obesity » Volume 16 Authors Sheng X, Li T, Hu Y, Xiong CS, Hu L Received 21 April 2023 Accepted for publication 21 July 2023 Published 16 August 2023 Volume 2023:16 Pages 2447—2456 DOI https://doi.org/10.2147/DMSO.S418224 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Konstantinos Tziomalos Xia Sheng, Ting Li, Yi Hu, Cheng-Shun Xiong, Ling Hu Department of...
IJERPH | Free Full-Text | Associations between Primary Healthcare Experiences and Glycemic Control Status in Patients with Diabetes: Results from the Greater Bay Area Study, China
4. Discussion In this study, we found positive associations between experiences of PHC in CHCs and glycemic control status in patients with diabetes. Our results provided additional evidence that diabetes may be addressed more effectively from improving DM patients’ experiences of PHC. To the best of our knowledge, this study is the first one published to analyze the association between DM patients’ experiences in CHCs and glycemic control status in China.
Enrichment of glycopeptides using environmentally friendly wood materials
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Increasing the Efficiency of Photocatalytic Reactions via Surface Microenvironment Engineering
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVCommunicationNEXT Hang Zhou Hang Zhou College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China Xia Sheng Xia Sheng College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R.
Interactions between metabolism regulator adiponectin and intrinsic cardiac autonomic nervous system: A potential treatment target for atrial fibrillation
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Study protocol, anatomical drawing of GP and effects of APN on the atrial electrophysiological parameters. (A) Schematic overview of the experimental design. (B C) The catheter position in the atria and PVs. (D-E) The anatomical position of the GP. (F-K) APN treatment significantly reversed the ERP decrease induced by RAP.
Paired electrocatalytic oxygenation and hydrogenation of organic substrates using water as oxygen and hydrogen source
Communication Paired electrocatalytic oxygenation and hydrogenation of organic substrates using water as oxygen and hydrogen source Licheng Sun Corresponding Author E-mail address: lichengs@kth.se Kungliga Tekniska Hogskolan Kista, Department of Chemistry, Teknikringen 30, KTH Royal Institute of Technology, 10044 Stockholm, SWEDEN Search for more papers by this author PDF PDF Share Abstract In natural systems, water is widely used as both an oxygen and hydrogen source for biosynthesis.
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Abstract Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs.
Length-Independent Charge Transport of Well-Separated Single-Crystal TiO2 Long Nanowire Arrays
Long, well-separated single crystal TiO2 nanowire (NW) arrays with rapid charge tranpsort properties hold great promise in photoelectrochemical and energy storage devices. Synthesis variations to increase the nanowire length generally result in widening of the NWs and fusion at their roots which, in turn, increases the structural disorder and slows charge transport.
Transformation from persistent atrial fibrillation to paroxysmal type after initial ablation predicts success of repeated ablation
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. FiguresFig. 1Kaplan–Meier curves compared AT/AFL/AF free survival after repeated procedure between Group A (recurrence with paroxysmal AF) and Group B (recurrence with persistent AF). (A) Including all enrolled patients; (B) excluding patients who were on amiodarone when recurrent AF after initial ablation was identified.
Maternal lead exposure and premature rupture of membranes: a birth cohort study in China
China is the largest Pb (raw and refined) producing and consuming country in the world. 23 Pb pollution poses a significant threat to human health, especially for pregnant women and the vulnerable fetuses, who are more susceptible to Pb exposure since Pb can freely cross the placenta. 24 Given this background, the present study involving 7290 participants was designed to explore whether Pb exposure during pregnancy could increase the risk of PROM and preterm PROM in Chinese pregnant women.
Upgrade to his bundle pacing in pacing-dependent patients referred for pulse generator change: Feasibility and intermediate term follow up
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. FiguresFig. 1Flowchart of the HBP upgrade in chronically right ventricular paced patients for generator change.Fig. 2Patients dynamic responses to permanent HBP during the follow up. Changes of EF (A) and LVIDd (B) in all patients (n = 12). Changes of EF (C) and LVIDd (D) in patients with EF ≥ 40%(n = 3).
Permanent his bundle pacing: A physiological alternative to conventional right ventricular pacing or just a futile artifice?
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. His bundle pacing (HBP) is a pacing technique proposed in last three decades to obtain a more physiological electro-mechanical activation of the ventricles. To access this article, please choose from the options below Purchase access to this article Claim Access If you are a current subscriber with Society Membership or an Account Number, claim your access now.
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin
Metabolism Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin Xia Sheng, Jean-Hugues Parmentier, Jonathan Tucci, Hua Pei, Omar Cortez-Toledo, Christina M. Dieli-Conwright, Matthew J. Oberley, Michael Neely, Etan Orgel, Stan G. Louie and Steven D. Mittelman
Enhanced Photocatalytic Reaction at Air-Liquid-Solid Joint Interfaces
Semiconductor photocatalysis has long been considered as a promising approach for water pollution remediation. However, limited by the recombination of electrons and holes, low kinetics of photocatalysts and slow reaction rate impede large-scale applications. Herein, we addressed this limitation by developing a triphase photocatalytic system in which a photocatalytic reaction is carried out at air–liquid–solid joint interfaces.
A room temperature approach for the fabrication of aligned TiO2 nanotube arrays on transparent conducting substrate
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Understanding and removing surface states limiting charge transport in TiO2 nanowire arrays for enhanced optoelectronic device performance
Charge transport within electrode materials plays a key role in determining the optoelectronic device performance. Aligned single-crystal TiO nanowire arrays offer an ideal electron transport path and are expected to have higher electron mobility. Unfortunately, their transport is found not to be superior to that in nanoparticle films.
Iron-containing N-doped carbon electrocatalysts for the cogeneration of hydroxylamine and electricity in a H2-NO fuel cell
Iron-containing N-doped carbon materials were investigated as electrocatalysts for the cogeneration of hydroxylamine (NH OH) and electricity in a H –NO fuel cell. This electrochemical route for the production of hydroxylamine is a greener alternative to the present industrial synthesis, because it allows converting the energy released during the reaction into electricity.
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