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Deficiency of Trex1 leads to spontaneous development of type 1 diabetes - Nutrition & Metabolism
Wild-type and Trex1−/− Sprague Dawley (SD) rats were obtained from Nanjing Biomedical Research Institute of Nanjing University based on CRISPR-Cas9 technology. The guide RNA sequence is as follows: 5′-GTCCACCACACGGGGTGGTT-3′. All rats were housed on a 12 h light/dark cycle with ad libitum access to food and water.
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