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Mediator subunit MED16 cooperates with UBP1-TFCP2 to control the promoter context-dependent transcriptional activity
Abstract The Mediator complex acts as a master transcriptional co-regulator, yet the mechanisms by which its individual subunits mediate gene-specific transcription remain incompletely defined. Here, we report that the Mediator subunit MED16 physically associates with the UBP1-TFCP2 heterodimer, which controls the context-dependent transcriptional activation or repression. Biochemical purification combined with mass spectrometry validated MED16 as a bona fide interactor of UBP1-TFCP2.
Pressure Induced Blue Shift Emission and Its Influence on the Band Gap in an Emerging 3D Semiconductor †
Pressure Induced Blue Shift Emission and Its Influence on the Band Gap in an Emerging 3D Semiconductor † Metal-organic chalcogenolate is one of excellent hybrid semiconductors, yet reports on their precise structures remain limited due to their large structural periodicity. Understanding the relationship between their structure and optical properties remained a significant challenge.
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