Xiaduo Meng on Muck Rack

Xiaduo Meng

As seen in: Nature
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Articles

Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour

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By Chen Wang, Yi Pan, Ruochen Dong, Wenxuan Zhou, Xiaduo Meng, Ravi Nistala, Richard Hammer, Linheng Li, Xunlei Kang
| Nature Verified
Abstract Leukaemic stem cells (LSCs) reside in protective bone marrow (BM) niches that promote therapeutic resistance and relapse. Here we characterized longitudinal BM niches supporting LSC survival, distinguishing the metaphysis from the central marrow. Quiescent LSCs preferentially localized to the metaphysis and exhibited reduced stemness and aggressiveness upon mobilization to the central marrow.
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WITHDRAWN: A Druggable Tumor Suppressor and Leukemic Stem Cell Marker

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By Yi Pan, Chen Wang, Xiaduo Meng
| biorxiv.org
Abstract The authors have withdrawn this preprint because the co-authors were not in agreement about posting the work in its current form. The authors request that this work not be cited. Please contact the corresponding author (Dr. Xunlei Kang, kangxu{at}health.missouri.edu) with questions. Competing Interest Statement The authors have declared no competing interest.
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