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Xianchan Li on Muck Rack

Xianchan Li

As seen in: Nature, Royal Society of Chemistry
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Articles

MicroRNA-132/212 negatively modulates opioid reward by targeting dopamine transporter in the ventral tegmental area - Translational Psychiatry

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By Jie Meng, Zhonghao Li, Yi Zhang, Dajun Zhang, Haiting Liu, Xiangyang Zang, Yaqiong Zhao, Jing Wen, Wei Shu, Xianchan Li, Yan-Xue Xue, Xiaojian Jia, Xiaoke Nan
| Nature Verified
Abstract Addictive drugs, notably opioid drugs, have significant societal implications, yet the cellular and molecular mechanisms underpinning rewarding effects remain largely elusive. Noncoding transcripts, including the microRNAs (miRNAs), are pivotal regulators of diverse biological functions. Notably, the microRNAs miR-132 and miR-212, arising from a shared noncoding transcript, have links to several psychiatric conditions, including cocaine addiction.
Open in Who Shared Issue with article?

Electrochemical Quantification of Transmitter Concentration in Single Nanoscale Vesicles Isolated from PC12 Cells

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By Johan Dunevall, Andrew Ewing, Xianchan Li
| Royal Society of Chemistry Verified
We use an electrochemical platform, nanoparticle tracking analysis, and differential centrifugation of single catecholamine vesicles to study the properties of nanometer transmitter vesicles, including the number of molecules, size, and catecholamine concentration inside. Vesicle impact electrochemical cytometry (VIEC) was used to quantify the catecholamine content of single vesicles in different batches isolated from pheochromocytoma (PC12) cells with different ultracentrifugation speeds.
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