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Articles by Xianding Deng
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Highlights 1. The B.1.427/B.1.429 variant grew to >50% of cases in California by early 2021. 2. The variant is 20% more transmissible with 2-fold increased shedding in vivo. 3. The variant has a spike L452R mutation conferring increased infectivity in vitro. 4. Antibody neutralization is reduced in COVID-19 patients and vaccine recipients.
Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation
Xianding Deng, Miguel A Garcia-Knight, Mir M Khalid, Venice Servellita, Candace Wang, Mary Kate Morris, Alicia Sotomayor-Gonzalez, Dustin R Glasner, Kevin R Reyes, Amelia S Gliwa, Nikitha P Reddy, Claudia Sanchez San Martin, Scot Federman, Jing Cheng, Joanna Balcerek, Jordan Taylor, Jessica A Streithorst, Steve Miller, G.
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Epidemic in Northern California Genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks is valuable for tracing the sources and perhaps for drawing lessons about preventing future outbreaks. Genomic analysis by Deng et al. revealed that Northern California experienced a complex series of introductions of the virus, deriving not only from state-to-state transmission but also from international travel by air and ship.
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Abstract The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship.
A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage
A Genomic Survey of SARS-CoV-2 Reveals Multiple Introductions into Northern California without a Predominant Lineage Xianding Deng, Wei Gu, Scot Federman, Louis Du Plessis, Oliver Pybus, Nuno Faria, Candace Wang, Guixia Yu, Chao-Yang Pan, Hugo Guevara, Alicia Sotomayor-Gonzalez, Kelsey Zorn, Allan Gopez, Venice Servellita, Elaine Hsu, Steve Miller, Trevor Bedford, Alexander Greninger, Pavitra Roychoudhury, Michael Famulare, Helen Y Chu, Jay Shendure, Lea Starita, Catie Anderson, Karthik...
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