Xianfang Shen on Muck Rack

Xianfang Shen

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Long noncoding RNA FOXP1-DT modulates regulatory T cells in Graves’ disease

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By qian Xu, Mengli Zhou, Shanshan Li, Shengjun Wang, Yingzhao Liu, Huiyong Peng, Chuanbin Lu, Xianfang Shen
| Nature
Abstract Regulatory T cells (Tregs) are key contributors to maintaining immune system stability, and their impairment has been linked to the pathogenesis of Graves’ disease (GD). However, the precise molecular mechanisms driving Treg dysregulation in GD remain poorly understood. Our previous study identified a dysregulated long noncoding RNA, FOXP1-DT (forkhead box P1 divergent transcript), which might be related to Treg cells.
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