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Abstract Activation of hepatic stellate cells (HSCs) is a pivotal event driving fibrogenic remodeling of the injured liver. However, the upstream regulators that integrate post-translational signaling with metabolic reprogramming during HSC activation remain poorly defined. Here, we identify pre-mRNA processing factor 19 (PRPF19) as a ubiquitination-linked metabolic regulator that promotes HSC activation.
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description liv70527-sup-0001-Supinfo.zipZip archive, 1.7 MB Figure S1: IAA administration alleviates the changes of body weight, liver weight and white adipose tissue weight of CDAHFD or HFHFrC fed mice.
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