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Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China
1 BACKGROUND Cerebral amyloid angiopathy (CAA) is an age-related disease characterized by the deposition of the amyloid beta (Aβ) protein in the walls of cerebral vessels.1-3 The apolipoprotein E (APOE) ε4 allele is a major risk factor for both Alzheimer's disease (AD) and CAA, whereas APOE ε2 is a risk factor for hemorrhagic CAA.4-7 There are three stages of pathologic development according to the distribution of CAA among brain regions.8-10 Although a set of clinical and radiological...
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