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Xianguo Xie

As seen in: MDPI
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Articles

Molecules | Free Full-Text | Human Pluripotent Stem Cell-Mesenchymal Stem Cell-Derived Exosomes Promote Ovarian Granulosa Cell Proliferation and Attenuate Cell Apoptosis Induced by Cyclophosphamide in a POI-Like Mouse Model

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By Lifan Zhang, Yabo Ma, Xianguo Xie, Changzheng Du
| MDPI
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Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen

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By Yan Zhang, Changzheng Du, Xianguo Xie, Yabo Ma
| MDPI
Abstract : Simple Summary Hyperandrogenemia (HA) is the main pathophysiological change that takes place in polycystic ovary syndrome (PCOS). Cyproterone acetate (CYA) is a drug commonly used to reduce androgen in patients with PCOS. Long-term and continuous exposure to hyperandrogen can cause ovarian granulosa cells (GCs), pyroptotic death, and follicular dysfunction in PCOS mice.
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