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Xiangying Deng on Muck Rack

Xiangying Deng

As seen in: Nature
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Articles

Tumor-infiltrating B cells inhibit nasopharyngeal carcinoma metastasis

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By Jing Cai, Xiangzhou Tan, Xinglong Liu, Juan Feng, Xiangying Deng, Lin Zhao
| Nature Verified
Abstract Nasopharyngeal carcinoma (NPC) in advanced stages often has a poor prognosis due to distant metastasis, yet the distribution characteristics and anti-metastatic mechanisms of tumor-infiltrating B cells (TIL-B) remain unclear. In this study, single-cell RNA sequencing combined with multiplex immunofluorescence revealed that B cells were highly enriched in non-metastatic NPC and formed complete tertiary lymphoid structures (TLS), whereas TLS was absent in metastatic NPC.
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Arvanil reverses cisplatin resistance in ovarian cancer by activating HMOX1-driven ferroptosis

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By Xinglong Liu, Lin Zhao, Yi Sun, Zhongping Zhou, Nuojie Luo, Xiangying Deng
| Nature Verified
Abstract Cisplatin resistance limits the effectiveness of ovarian cancer (OC) therapy. Arvanil is a synthetic capsaicin derivative with favorable pharmacokinetic properties. This study showed that Arvanil enhances the anti-tumor effect of cisplatin in cisplatin-resistant ovarian cancer cells, partly associated with HMOX1-related ferroptosis.
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