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Xianming Yin

As seen in: Frontiers
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Articles

Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation

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By Wen Wang, Yanan Wei, Wenxue Sun, Yanqiu Wei, Juanjuan Shi, Shouhui Chai, Xianming Yin
| Frontiers
Abstract Background: Perimenopause represents a pivotal transitional stage in female reproductive aging, often accompanied by neurological disorders such as cognitive decline. However, the underlying molecular mechanisms remain incompletely understood. Methods: In this study, a total of 18 eight-week-old female Sprague–Dawley (SD) rats were randomly divided into the control group and the perimenopausal syndrome (PMS) model group induced by bilateral ovariectomy (OVX).
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