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Xianying Zeng on Muck Rack

Xianying Zeng

As seen in: Emerging Infectious Diseases, Nature, Wiley Online Library, BioRxiv, Journal of Infection
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Articles

A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections

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By Yichao Zhuang, Lei Chen, Chen Qin, lulu feng, Weipeng Lin, Jiaqi Li, Yaping Zhang, Congcong Wang, Jianzhong Shi, Guohua Deng, Xianying Zeng, Pengfei Cui, Yanbing Li, Yongping Jiang, Hualan Chen, Huihui Kong, Puze Chen
| Nature Verified
Abstract Influenza A viruses continue to pose a major threat to global public health. In addition to H1N1 and H3N2 subtypes causing seasonal epidemics that result in an estimated 3–5 million severe cases and 290,000–650,000 deaths annually, other subtypes, including avian H5, H7, and H9, have shown cross-species transmission potential, leading to thousands of human infections in multiple countries.
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Un1Cas12f1 and Cas9 gene drive in HSV1: Viruses that 'infect' viruses

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By Qiaorui Yao, Zhuangjie Lin, Keyuan Lai, Xianying Zeng
| BioRxiv
Abstract Synthetic CRISPR-Cas9 gene drive has been developed as a potential tool to control harmful species. However, Cas9 gene drive faces high resistance rate and mitigation strategies developed so far are difficult to implement. Furthermore, studying the resistance to gene drive is time consuming and challenging in higher organisms. We here tackled these two challenges simultaneously by generating Cas9 and Un1Cas12f1 gene drive in a fast-replicating DNA virus, HSV1.
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Genetics and Pathogenicity of Influenza A (H4N6) Virus Isolated from Wild Birds in Jiangsu Province, China, 2023

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By Xingdong Song, Jingman Tian, Minghui Li, Xiaoli Bai, Zhiguo Zhao, Jianzhong Shi, Xianying Zeng, Guobin Tian, Yuntao Guan, Pengfei Cui, Guohua Deng
During the routine surveillance, we isolated nine H4N6 subtype avian influenza viruses (AIVs) in Jiangsu Province, China, in March 2023. Phylogenetic analysis revealed that nine H4N6 viruses belonged to the Eurasian lineage and underwent complex genetic recombination among Asian countries during their evolution. It is particularly noteworthy that the PB2 and PB1 genes of our representative virus were descended from clade 2.3.4.4b H5 high-pathogenic AIVs in Japan.
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