Xianzhou Huang

Keywords harmless-harmful switchable spatiotemporally activated ferroptosis CRISPR/Cas9 cancer therapy Introduction Ferroptosis, an iron-dependent cell death form, has sparked great interest in treatment of cancer, which is caused by lipid membrane rupture due to the overwhelming accumulation of lipid peroxide (LPO).1,2,3,4 Ferroptosis heavily relies on the intracellular iron ion level and the reactive oxygen species (ROS) level.5,6 The iron-mediated Fenton reaction converts endogenous H2O2...

1 Introduction Tumor environment is a dynamic coevolution product of tumor cells and corresponding stromata.[1-5] This reciprocal interaction results in high microvascular density, cancer associated fibroblast (CAF) activation and abundant desmoplasia to form and support the fibrosis environment, as an “indestructible fortress”, in malignant solid tumors, such as triple negative breast cancer (TNBC).[5-10] While new vessels foster and accelerate tumor progression and aggression, CAFs build up...