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Articles by Xiaochen Tang
Dynamic, differentiated clinical trajectories and prediction in clinical high risk for psychosis
Abstract Clinical subtypes of individuals at clinical high risk for psychosis (CHR), classified by baseline symptoms and cognitive performance, may follow distinct trajectories of symptom progression and functional outcomes. Baseline symptom, cognitive and EEG data were collected from 204 CHR individuals aged 13–38 years, who subsequently completed clinical assessments at 2 months, 1 year, and 2 years.
Quantitative reference levels for thirdhand smoke residue from tobacco products in indoor environments: a systematic review and meta-analysis
Abstract Commercial tobacco use leaves hazardous chemical residues in indoor environments, known as thirdhand smoke. The residue has been found to be highly persistent and can still be detected months and years after indoor smoking has ceased. This systematic review synthesizes studies that measure surface wipe nicotine, a validated thirdhand chemical marker, to propose reference levels for indoor thirdhand smoke contamination.
Reversible Quantum Dot-Driven Multiplex Technology for In Situ Subcellular Structure Imaging Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Traditional immunofluorescence methods and organic fluorescent dyes can achieve localized staining analysis of organelle structures, but they often face challenges, such as fluorescence signal quenching, limited detection throughput, and complex antibody modification. To address these issues, we developed ssDNA-quantum dot imaging encoding (ssQIE), an in situ imaging method that combines quantum dots with DNA nanotechnology.
Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort
Abstract The T Helper (Th)1-Th2 imbalance has been observed during the transition from the clinical high-risk (CHR) state to psychosis. However, it remains unclear whether the complement system influences this imbalance during psychosis onset. This study aimed to investigate the dynamic interplay between complement activation and the Th1-Th2 balance during the progression of psychosis.
Enzymatic colorimetric encoding-based digital medicine for pancreatic cancer diagnosis
Abstract Digital medicine leverages digital biomarkers by algebraically integrating multiple biomarkers to reflect disease status. Colorimetric analysis offers an intuitive readout, but colorimetric-based digital medicine remains underexplored. Here we show an Enzymatic Colorimetric Encoding-based Digital Medicine platform (EnCODE).
The impact of disparities in collaborators’ encoding levels on collaborative memory
Utilising a two-character Chinese compound words list as task material, this study examines the effects of three combinations of deep and shallow encoding levels (operationalised via semantic and perceptual tasks, respectively) of two members within the same collaborative group on collaborative retrieval and subsequent individual memory. During the encoding phase, both the collaborative group and the nominal group conducted independent semantic or perceptual encoding.
DNA self-assembly encoding in spatial multi-omics imaging
Keywords DNA self-assembly spatial multi-omics multiplex analysis DNA encoding Introduction DNA serves not only as the carrier of biological genetic information but also as a class of biomaterials with exceptional sequence designability, programmability, and ease of synthesis.1 By leveraging the strict base-pair complementarity principle, DNA can be rationally engineered to self-assemble into predetermined architectures, which offers researchers vast design flexibility and establishes a...
Secondhand Exposure to Simulated Cannabis Vaping Aerosols
Occurrence, Fate, and Transport of Contaminants in Indoor Air and AtmosphereMay 12, 2025 * Vi H. Rapp Indoor Environment Group, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Sharon Chen Indoor Environment Group, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Marion L.
Resiliencia de la red cerebral y función cognitiva en pacientes con primer episodio de trastornos del espectro esquizofrénico
Me Gusta 1 1 Comentar 2 2 Autor/autores: Soyolsaikhan Odkhuu, XiaoChen Tang, Woo-Sung Kim...(et.al) Fecha de publicación: 30/04/2025 Artículo | Artículo revisado por nuestra redacción Introducción Los trastornos del espectro de la esquizofrenia de primer episodio (FESSDs) están asociados con deterioros cognitivos significativos que afectan el funcionamiento diario de los pacientes.
Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity | Schizophrenia
Abstract To explore the neurobiological heterogeneity within the Clinical High-Risk (CHR) for psychosis population, this study aimed to identify and characterize distinct neurobiological biotypes within CHR using features from resting-state functional networks. A total of 239 participants from the Shanghai At Risk for Psychosis (SHARP) program were enrolled, consisting of 151 CHR individuals and 88 matched healthy controls (HCs).
Dynamic Addressing Molecular Robot (DAMR): An Effective and Efficient Trial‐and‐Error Approach for the Analysis of Single Nucleotide Polymorphisms
1 Introduction Accurate and efficient molecular recognition serves as the cornerstone in the fields of molecular detection and molecular diagnostics.[1] Previous strategies for target analysis in complex systems based on molecular recognition rely on trial-and-error approaches in which non-targets that bind to the recognizers, or targets that bind to the non-recognizers can be reversibly released until the correct molecule recognition [2] (Figure 1a).
Cognitive Impairments in Drug-Naive Patients With First-Episode Negative Symptom-Dominant Psychosis
Key Points Question Does a distinct subtype of first-episode psychosis (FEP) characterized by predominant negative symptoms (negative symptom–dominant [NSD] psychosis) exhibit specific cognitive impairments? Findings In this cross-sectional study, 788 patients with NSD exhibited more pronounced cognitive impairment compared with those with positive symptom–dominant or general symptom–dominant psychosis, particularly in processing speed and attention domains.
Association between serum cytokines and timeframe for conversion from clinical high‐risk to psychosis
Supporting Information Filename Description pcn13670-sup-0001-Supinfo.docxWord 2007 document , 18.6 KB Table S1. Baseline demographic, clinical and cytokine variables in individuals with CHR who later converted to overt psychosis (CHR-P), CHR individuals who did not develop psychosis (CHR-NP), and healthy control subjects (HC). Table S2.
Proximity‐Enhanced Functional Imaging Analysis of Engineered Tumors
Conflict of interest The authors T.C., D.M., X.Z. and Q.P. are inventors on a patent application titled “Method and application for functional imaging of cells based on differences in glycometabolism”. The other authors declare no competing interests. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset.
Duration of Untreated Prodromal Psychosis and Cognitive Impairments
Key Points Question Is the duration of untreated prodromal symptoms (DUPrS) associated with cognitive performance and risk of conversion to psychosis in individuals at clinical high risk (CHR) for psychosis? Findings In this cohort study of 506 individuals at CHR for psychosis with 4 years’ follow-up, the DUPrS was associated with cognitive performance and the risk of conversion to psychosis.
DNA-Programmed Four-Bit Quaternary Fluorescence Encoding (FLUCO) Enables 51-Colored Bioimaging Analysis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
DNA-Programmed Four-Bit Quaternary Fluorescence Encoding (FLUCO) Enables 51-Colored Bioimaging Analysis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Metabolic Glycoengineering-Programmed Nondestructive Capture of Circulating Tumor Cells
RETURN TO ARTICLES ASAPPREVBiological and Medic...Biological and Medical Applications of Materials and InterfacesNEXT Runchi Zhang Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, P. R. China , Siyu Cao Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R.
Enzyme Reaction-Assisted Programmable Transcriptional Switches for Bioactive Molecule Detection
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Remediation of Thirdhand Tobacco Smoke with Ozone: Probing Deep Reservoirs in Carpets
We assessed the efficacy of ozonation as an indoor remediation strategy by evaluating how a carpet serves as a sink and long-term source of thirdhand tobacco smoke (THS) while protecting contaminants absorbed in deep reservoirs by scavenging ozone. Specimens from unused carpet that was exposed to smoke in the lab (“fresh THS”) and contaminated carpets retrieved from smokers’ homes (“aged THS”) were treated with 1000 ppb ozone in bench-scale tests.
Emissions from Heated Terpenoids Present in Vaporizable Cannabis Concentrates
Vaporizable cannabis concentrates (VCCs) consumed as a liquid (vaping) or a waxy solid (dabbing) are becoming increasingly popular. However, their associated emissions and impacts have not been fully described. Mixtures containing different proportions of 12 VCC terpenoids and high MW compounds were heated at 100–500 °C inside a room-sized chamber to simulate emissions. Terpenoids, thermal degradation byproducts, and ultrafine particles (UFPs) were quantified in the chamber air.
When to initiate antipsychotic treatment for psychotic symptoms: At the premorbid phase or first episode of psychosis?
Addington, J, Epstein, I, Liu, L, et al. (2011) A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis. Schizophrenia Research 125: 54–61. Google Scholar | Crossref | Medline | ISI Albert, N, Glenthoj, LB, Melau, M, et al. (2017) Course of illness in a sample of patients diagnosed with a schizotypal disorder and treated in a specialized early intervention setting. Findings from the 3.5-year follow-up of the OPUS II study.
Modeling the Time-Dependent Concentrations of Primary and Secondary Reaction Products of Ozone with Squalene in a University Classroom
Volatile organic chemicals are produced from reactions of ozone with squalene in human skin oil. Both primary and secondary reaction products, i.e., 6-methyl-5-hepten-2-one (6-MHO) and 4-oxopentanal (4-OPA), have been reported in indoor occupied spaces. However, the abundance of these products indoors is a function of many variables, including the amount of ozone and occupants present as well as indoor removal processes.
Heated Tobacco Products: Volatile Emissions and Their Predicted Impact on Indoor Air Quality
This study characterized emissions from IQOS, a heated tobacco product promoted as a less harmful alternative to cigarettes. Consumable tobacco plugs were analyzed by headspace GC/MS to assess the influence of heating temperature on the emission profile. Yields of major chemical constituents increased from 4.1 mg per unit at 180 °C to 6.2 mg at 200 °C, and 10.5 mg at 220 °C.
Predicting Indoor Emissions of Cyclic Volatile Methylsiloxanes from the Use of Personal Care Products by University Students
Characterization of indoor emissions of cyclic volatile methylsiloxanes (cVMS) due to the use of personal care products is important for elucidating indoor air composition and associated health risks. This manuscript describes a mass transfer model to characterize the emission behaviors of decamethylcyclopentasiloxane (D5, the most abundant indoor cVMS) from skin lipids.
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