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Articles by Xiaodan Lu
Excess copper compromises hippocampal function in major depressive disorder: a study on clinical and animal evidence
Abstract Dysregulation of copper (Cu) metabolism may contribute to the pathogenesis of major depressive disorder (MDD) by disrupting hippocampal function. The aim of this study is to elucidate the neurobiological mechanisms through integrated clinical and animal experiments. A total of 85 MDD patients and 65 healthy controls (HCs) were recruited for this study. Serum Cu, ceruloplasmin (Cp) levels, and the relative mRNA expression of ATPase copper-transporting alpha (Atp7a) were measured.
Secreted SULF1 protein modulates CD8 + T cell exhaustion by promoting TAM polarization in gastric cancer
Abstract Gastric cancer (GC) progression is linked to immune escape in the tumor microenvironment, yet the molecules regulating tumor-associated macrophage polarization and CD8+ T-cell exhaustion are unclear. This study analyzed TCGA data to examine SULF1 expression and its prognostic role. It used CRISPR/Cas9 and lentiviral methods in GC cells to test proliferation, invasion, and apoptosis, plus co-culture and flow cytometry to assess SULF1’s impact on macrophages and CD8+ T-cells.
Large language model detects previously undiagnosed heart failure with preserved ejection fraction in patients with metabolic-associated fatty liver disease: A multicenter cohort study
Loading metrics Open Access Peer-reviewed Research Article Citation: Lu X, Wang X, Liu D, Zhang Z, Zhang Y, Zhang T, et al. (2026) Large language model detects previously undiagnosed heart failure with preserved ejection fraction in patients with metabolic-associated fatty liver disease: A multicenter cohort study. PLOS Digit Health 5(3): e0001317.
Effects of WN1703 on Cardiovascular Function in Chronic Hyperuricemia Rats and Myocardial Injury Mechanism Exploration in H9C2 Cells
Conflicts of Interest The authors declare no conflicts of interest. References , , , et al. 2013. “Rho-Kinase: Regulation, (Dys)function, and Inhibition.” Biological Chemistry 394, no. 11: 1399–1410. https://doi.org/10.1515/hsz-2013-0181. 2017. “Post-Marketing Drug Withdrawals: Pharmacovigilance Success, Regulatory Problems.” Thérapie 72, no. 5: 555–561. https://doi.org/10.1016/j.therap.2017.02.005. , and . 2020. “FAST: New Look at the Febuxostat Safety Profile.” Lancet 396, no. 10264: 1704–1705.
O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification: Emerging pathogenesis and a therapeutic target of diabetic nephropathy
Abnormal activation of O-linked β-N-acetylglucosamine (O-GlcNAc) modification is implicated in diabetic nephropathy. This review article summarizes the mechanisms by which O-GlcNAcylation of proteins mediates renal cell damage and promotes renal interstitial fibrosis, leading to diabetic nephropathy. Current treatments of diabetic nephropathy have also been shown to regulate protein O-GlcNAcylation.
A survey of skin failure perceptions amongst pressure injury management staff in China: A cross‐sectional study
1 INTRODUCTION In 1991, La Puma initially proposed that the skin, being the largest organ in the body, is susceptible to failure like any other organ.1 Skin failure (SF) is defined as the necrosis of the skin and subcutaneous tissue triggered by haemodynamic instability, resulting in inadequate perfusion, often accompanied by severe dysfunction or failure of other organ systems.2 SF can manifest anywhere on the body, presenting as pear-shaped, butterfly-shaped or horseshoe-shaped flat red or...
Aflatoxin Exposure From Oil And Foods During Pregnancy
Back to Journals » International Journal of General Medicine » Volume 17 Original Research General Medicine Authors Zhong Y , Lu H, Lu X, He Z, Jiang Y, Chen J, Liabsuetrakul T Received 7 December 2023 Accepted for publication 2 March 2024 Published 27 March 2024 Volume 2024:17 Pages 1171—1184 DOI https://doi.org/10.2147/IJGM.S453839 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Woon-Man Kung Yanxu Zhong,1,2 Huan...
Assessment of the Adverse Health Effects of Aflatoxin Exposure from Unpackaged Peanut Oil in Guangdong, China
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Gut microbiome-serum metabolism profiles insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice
Gut microbiome-serum metabolism profiles insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice Yujia Ou, Yuehong Guo, Mingrong Chen, Xiaodan Lu, Zebin Guo and Baodong Zheng Abstract The hypoglycemic activity of natural algal glycoproteins has attracted interest, but studies of their mechanism of regulating glucose metabolism are lacking.
Structure and Antidiabetic Activity of a Glycoprotein from Porphyra haitanensis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Structure and Antidiabetic Activity of a Glycoprotein from Porphyra haitanensis
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Effect of DHA-Enriched Phospholipids from Fish Roe on Rat Fecal Metabolites: Untargeted Metabolomic Analysis
Abstract : Lipid metabolism disorder has become an important hidden danger threatening human health, and various supplements to treat lipid metabolism disorder have been studied. Our previous studies have shown that DHA-enriched phospholipids from large yellow croaker (Larimichthys Crocea) roe (LYCRPLs) have lipid-regulating effects.
The Anti-Fatigue Effect of Glycoprotein from Hairtail Fish (Trichiurus lepturus) on BALB/c Mice
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Transcriptomics Dissection of Calorie Restriction and Exercise Training in Brown Adipose Tissue and Skeletal Muscle
Abstract : Calorie restriction (CR) and exercise training (EX) are two critical lifestyle interventions for the prevention and treatment of metabolic diseases, such as obesity and diabetes. Brown adipose tissue (BAT) and skeletal muscle are two important organs for the generation of heat. Here, we undertook detailed transcriptional profiling of these two thermogenic tissues from mice treated subjected to CR and/or EX.
DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet
DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In previous research, we studied the effect of LYCRPLs on the inhibition of triglyceride accumulation at the cellular level.
Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
White fat can undergo “browning” and acquire some of the energy-burning properties of brown fat in response to various stimuli, such as β -adrenergic receptor activation. Mitophagy, a specialized autophagic process that degrades mitochondria, causes these beige adipocytes to reacquire the fat-storing characteristics of white adipocytes. Using mouse models and cultured beige adipocytes, Lu et al.
A highly selective and sensitive fluorescent chemosensor for detection of CN−, SO32− and Fe3+ based on aggregation-induced emission
A novel fluorescence chemosensor 1 with aggregation-induced emission was designed and synthesized through a nucleophilic addition reaction between cyanide and triphenylamine. It exhibited remarkable selectivity and high sensitivity and was able to detect Fe , CN and SO in almost pure aqueous solution with low detection limits of 1.44 μM, 9.88 nM and 0.107 μM, respectively. Job's plot and H NMR data showed that the binding stoichiometry of 1 with Fe , CN or SO was 1 : 1.
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