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A Comparative Proteomics Study of Autopsy and Fresh-Frozen Coronary Artery Samples
Introduction Click to copy section linkSection link copied! Despite advancements made by initiatives such as the Human Protein Atlas project, the comprehensive proteomic mapping of blood vessels remains inadequately addressed. Fresh-frozen human vessels, especially coronary arteries, are difficult to obtain.
A common gene signature of the right ventricle in failing rat and human hearts - Nature Cardiovascular Research
Abstract The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic changes occurring over months in isolated cardiomyocytes or whole heart tissues from failing right and left ventricles in rat models of pulmonary artery banding (PAB) or aortic banding (AOB).
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA - Nature Communications
Abstract The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise their function and cause cytotoxicity. Here we identify phenylalanine-tRNA synthetase (FARS) subunit alpha (FARSA) as the main interactor of the CCCCGG antisense repeat RNA in cytosol.
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