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Xiaolin Chen

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Articles

DDIT3, OTUB2, and ASS1 regulate arginine biosynthesis in colorectal cancer cells under arginine deficiency

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By Mengying Li, Jie Zhang, Xiaolin Chen, Xiuqun Zou, Jiamin Wang, Wenyan Huang, Haixia Peng, Hao Jia, Zhaoyuan Hou
| Cell Reports Verified
Keywords ASS1 ubiquitination OTUB2 AMPK DDIT3 C/EBPα arginine deprivation therapy ADT Research topic(s) CP: cancer CP: molecular biology Introduction Tumor cells rely on extensive nutrient consumption, such as glucose, nucleic acids, lipids, and amino acids to fuel rapid proliferation, invasion, immune evasion, and angiogenesis.1 Arginine, a semi-essential amino acid, plays dual roles in cellular metabolism: it serves as a critical intermediate in the urea cycle and as a primary substrate for...
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SEL1L3 suppresses colorectal cancer cell growth and metastasis by preventing endoplasmic reticulum-associated degradation of STING

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By Wenli Qian, Mengying Li, Xiaolin Chen, Keyan Miao, Jiali Dong, Jiamin Wang, Haixia Peng, Hao Jia, Zhaoyuan Hou, Xiuqun Zou, Mai Zhao, Mengjiang Xu
| Nature Verified
Abstract Endoplasmic reticulum associated degradation (ERAD) plays pivotal role in protein homeostasis and quality control in normal and cancer cells, yet the regulatory mechanism of ERAD remains elusive, especially regarding its ubiquitination function mediated by hydroxymethylglutaryl reductase degradation protein 1 (HRD1).
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Microplastics and nanoplastics in brain tumours and the healthy human brain

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By Fa Lin, Xiaoli Zhao, Junyu Wang, Miaomiao Teng, Chengjun Li, Li Ma, Huan Zhong, Yu Chen, Wenli Tang, Ke Wang, Jiaqi Sun, Zhenshan Song, Jionghao Xue, Minghao Liu, Yitong Jia, Genhuan Yang, Qingyuan Liu, Zenghui Qian, Wenying Qiu, Naili Wang, Zhen Chen, Wei Zhang, Shuai Kang, Hao Wang, Bobo Cao, Guozhi Cao, Shuo Wang, Chao Ma, Fengchang Wu, Dabiao Zhou, Yuanli Zhao, Jizong Zhao, Xiaolin Chen
| Nature Verified
Abstract Microplastics and nanoplastics (MNPs) are emerging global contaminants of concern, owing to their ability to penetrate human tissues, although their health risks are unknown. MNPs have been detected in several organs, including the brain, but their concentrations in, and effects on, this organ remain largely unexplored.
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