Skip To Main Content
Xiaolin Rao on Muck Rack

Xiaolin Rao

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Xiaolin

Contact Xiaolin, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

A hybrid system enables plasmid copy number control in yeast

|
By Anni Li, Qingyang Zhao, Dong Xu, Yueyao Zhang, Ting He, Bingzhao Zhuo, Xing Zhao, Hui Wang, Lizhu Chen, Zhouqing Luo, Zhunyi Yang, Jiesheng Cheng, Xiaolin Rao
| Nature Verified
Abstract Synthetic biology demands plasmid with tunable copy numbers. While dynamic plasmid copy number (PCN) regulation has been engineered in prokaryotes, a parallel capability remains unavailable in eukaryotic systems. Here, we develop a programmable PCN platform for S. cerevisiae based on the endogenous 2μ plasmid. The p2μ-Cir0 system achieves up to 20 copies per cell with enhanced homogeneity and stability, supporting 60-fold higher expression than chromosomal integration.
Open in Who Shared Issue with article?
See all 1 articles