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Xiaoming Zhou BS

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Articles

The role of ubiquitin pathway‐mediated regulation of immune checkpoints in cancer immunotherapy

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By Xiaoming Zhou, Chengxiao Fu, Xisha Chen, Xiaoming Zhou BS
| Wiley Online Library Verified
Abstract With the continuous cognition of the relationship between tumor cells and tumor immune microenvironment, immunotherapy based on the immune checkpoint blockade has achieved great breakthroughs, led to improved clinical outcomes, and prolonged survival for cancer patients in recent years. Nevertheless, the de novo or acquired resistance to immunotherapy has greatly counteracted the efficacy, leading to a 20%–40% overall response rate.
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