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Articles by Xiaoping Lei
Clinical efficacy and safety evaluation of dexmedetomidine hydrochloride nasal spray for sedation before examinations in children aged 2 to 6 years: protocol for a randomized controlled trial
Abstract Background: Children aged 2 to 6 years are prone to fear and resistance during medical examinations, necessitating sedation assistance. Traditional sedation modalities have limitations such as inconvenient operation, slow onset, or respiratory depression. Dexmedetomidine hydrochloride, a highly selective α₂-adrenergic receptor agonist, exerts sedative, analgesic, and anxiolytic effects with minimal respiratory and circulatory impacts.
LILRB2–TREM2 signalling as a candidate microglial checkpoint in white matter repair: an evidence-calibrated review informed by neuronal PirB
Abstract Background: White matter repair requires coordinated myelin-debris clearance, inflammatory resolution, oligodendrocyte precursor cell (OPC) differentiation, remyelination and adaptive circuit reorganization. Murine paired immunoglobulin-like receptor B (PirB) and the functionally corresponding human leukocyte immunoglobulin-like receptor B2 (LILRB2) occupy potentially important but incompletely defined positions within this sequence.
Pediatric early warning score and unplanned readmission with influenza at emergency observation room
1 Introduction Influenza virus (IV) is classified under the Orthomyxoviridae family of single-stranded RNA viruses (1). The Chinese National Influenza Center reported that influenza is a significant public health concern in China, especially for children. Between 2004 and 2020, the average annual incidence of influenza in mainland China was 31.57 cases per 100,000 people. In 2009 and 2019, there were notable outbreaks that exceeded the expected values by 142% and 323%, respectively (2).
Predictive value of biomarkers in neonatal necrotizing enterocolitis
1 Introduction Necrotizing enterocolitis (NEC) is a severe inflammatory intestinal disorder that poses a life threat to preterm infants and accounts for a major cause of death in neonatal intensive care units (NICUs) (1). This disease predominantly affects preterm infants (accounting for 90% of cases), with an incidence rate of 0.5‰–5.0‰ and a domestic mortality rate as high as 10%–50% (2, 3).
Spatiotemporal variation and multivariate controls of short‐cycle drought-flood abrupt alteration: A case in the Qinling‐Daba Mountains of China
A comprehensive understanding of the patterns of drought and flood alternation in adjacent months is essential for enabling climate adaptation and mitigation strategies. However, there is a paucity of knowledge regarding short-cycle drought–flood abrupt alteration (s-DFAA) and its responses to multiple environmental factors at various timescales.
Position management on pulmonary function and bronchopulmonary dysplasia in premature infants: study protocol for a randomised controlled trial
Methods and analysis Aim of the study This randomised controlled study investigates whether the prone position can improve pulmonary development and reduce the incidence of BPD in premature infants. Study design This single-centre, single-blind, randomised controlled trial will be performed at the Affiliated Hospital of Southwest Medical University. We will recruit participants according to strict inclusion and exclusion criteria.
Associations between prepregnancy body mass index, gestational weight gain and weight catch‐up in small‐for‐gestational‐age children
Abstract Inadequate gestational weight gain (GWG) was related with a higher incidence of small-for-gestational-age (SGA) births than appropriate GWG; however, the long-term association of maternal GWG with weight catch-up growth in SGA children remains unknown. The objective of this study is to evaluate the associations between prepregnancy body mass index (pBMI), GWG and weight catch-up patterns in SGA children.
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