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1 Introduction First-trimester miscarriage (or early pregnancy loss) is one of the most common complications in pregnancy.[1, 2] Approximately 15–25% pregnant women experience spontaneous miscarriage, and 1–5% suffer from recurrent miscarriage.[3] Many factors might induce miscarriage, including chromosomal abnormalities, uterine deformation, hormonal abnormalities, infections, psychological trauma and stressful life events, and immune disorders.[4] However, there are still 50% causes...
Xiaoping Yue conceived and designed the experiments, performed the experiments, analyzed the data, performed the computation work, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Chunna Zhang conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.
Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl α-Chloro β-Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem Xiaoping Yue, Yitong Li, Min-Jie Liu, Di Sang, Zedu Huang and Fen-Er Chen Abstract The first systematic study of ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) on aryl -chloro -keto esters was performed, and 15 structurally diverse chiral anti-aryl -chloro -hydroxy esters were synthesized in 74%-to-98%...
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