Xiaoru Yin

1 Introduction Crop diseases severely impact agricultural yield and quality, causing significant economic losses and threatening food security (Savary et al. 2019). Fungicides are critical tools for managing plant diseases; however, their overuse leads to the development and spread of pathogen resistance, ultimately undermining control efficacy (Lucas et al. 2015; Steinberg and Gurr 2020).

Agricultural and Environmental ChemistryOctober 23, 2025 Yige Li State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China Ziyang Zhang State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China Xiaoru Yin State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural...

eLife Assessment In this valuable study, the authors show the physiological response and molecular pathway mediating the effect of quinofumelin, a developed fungicide with an unknown mechanism. The authors present convincing data suggesting the involvement of the uridine/uracil biosynthesis pathway, by combining in vivo microbiology characterization as well as in vitro biochemical binding results.