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Xiaosong Wang MSc

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B-Cell Depletion Relative to Tumor Necrosis Factor Inhibition Extends the Duration of Viral Shedding in COVID-19 Among Autoimmune Disease Patients: A Matched Prospective Cohort Study

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By Liya Getachew, Immunity Brigham, Xiaosong Wang MSc, Xiaosong Wang, Naomi Patel, Zachary S. Wallace, Lauren O'Keeffe, Jiaqi Wang, Grace Qian, Alene Saavedra, Kevin Mueller, Natalie Davis, Yijia Li, Manish C. Choudhary, Madison Negron, Brooke M. Leeman
| Wiley Online Library Verified
INTRODUCTION Individuals with autoimmune diseases have been shown to be at a higher risk of infection with SARS-CoV-2.1, 2 The risk for acute and postacute severe COVID-19 outcomes such as hospitalization and death is also higher in these individuals.1 This elevated risk may be in part due to their immunosuppressive medications.3, 4 Medications such as B cell depleting (BCD) therapies and tumor necrosis factor inhibitors (TNFi) have an impact on the immune response against SARS-CoV-2.2, 5...
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