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Xiaoting Hong

As seen in: Nature, Frontiers in Immunology, Dove Medical Press
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Articles by Xiaoting Hong

A novel berberine derivative B12 exhibits superior anti-obesity effects via targeting brown and white adipocyte dynamics

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By Wenqing Zhang, Yanhong Feng, Chunyi Gao, Wenjun Wang, Bowen Zheng, Yuehua Zhang, Shengyu Wang, Shaoxiong Yi, Zufang Wu, Yongqing Lin, Beibei Xu, Sijie Cheng, Yan-yan Zhan, Shaoliang Zhang, Xiaoting Hong, Tianhui Hu, Linhai Zhong, Minying Xu
| Nature Verified
Abstract Obesity remains a global health challenge, with limited therapeutic options. Berberine (BBR) shows promise as an anti-obesity agent. However, its clinical application is hampered by modest efficacy and poor bioavailability. This study investigated the anti-obesity effects and underlying mechanisms of B12, a novel BBR derivative with enhanced solubility and bioavailability. Mice with obesity induced by a high-fat-diet were employed to evaluate B12’s effect on weight loss.
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YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT stabilization

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By Fen Wang, Zhengyang Zhao, Xiaolei Chen, Weihong Lu, Yanshuo Sun, Qingyuan Feng, Piao Xu, Lingjia Shen, Wenqing Zhang, Yan-yan Zhan, Tianhui Hu, Xiaoting Hong, Zhuanghua Li, Shuying Yao, Jiameng Xi, Huirou Luo, Shuguang Lv, Liangxi Xie
| Nature Verified
Abstract N6-methyladenosine (m6A) represents the most abundant internal RNA modification, and a key regulator of gene expression, yet its role in determining cell fate decisions such as senescence remains largely unexplored. Here, we identify the nuclear m6A reader YTHDC1 as a critical regulator of telomere homeostasis and senescence evasion in ovarian cancer. YTHDC1 expression was markedly elevated in advanced-stage tumors and correlated with poor patient survival.
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Bioinformatics based exploration of the anti-liver fibrosis mechanism of Pien Tze Huang via EGFR/JAK1/STAT3 pathway

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By Yonghua Ye, Fan Lin, Qing Xiong, Wei Xu, Huang Li, Yuqin Zhang, Xiaoting Hong, Chunfeng Lin, Miaolan Zheng, Haiyin Zheng
| Frontiers in Immunology
1Institute of Structural Pharmacology & Traditional Chinese Medicine (TCM) Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China 2College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China Object: Liver fibrosis is a key stage in chronic liver disease, but targeted treatments are scarce.
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Plant-Derived Exosome-like Nanoparticles: A promising therapeutic for | IJN

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By Miaolan Zheng, Xiaoting Hong, Han Huang, Penghua Liao
| Dove Medical Press
Back to Journals » International Journal of Nanomedicine » Volume 20 Authors Zheng M, Hong X, Liao P, Huang H, Zhang Y , Xu W , Li H Received 6 October 2025 Accepted for publication 11 December 2025 Published 26 December 2025 Volume 2025:20 Pages 15769—15791 DOI https://doi.org/10.2147/IJN.S572417 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Sachin Mali Miaolan Zheng,1,* Xiaoting Hong,1,* Penghua Liao,1...
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