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Zhuanghua Li on Muck Rack

Zhuanghua Li

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Articles

YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT stabilization

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By Fen Wang, Zhengyang Zhao, Xiaolei Chen, Weihong Lu, Yanshuo Sun, Qingyuan Feng, Piao Xu, Lingjia Shen, Wenqing Zhang, Yan-yan Zhan, Tianhui Hu, Xiaoting Hong, Zhuanghua Li, Shuying Yao, Jiameng Xi, Huirou Luo, Shuguang Lv, Liangxi Xie
| Nature Verified
Abstract N6-methyladenosine (m6A) represents the most abundant internal RNA modification, and a key regulator of gene expression, yet its role in determining cell fate decisions such as senescence remains largely unexplored. Here, we identify the nuclear m6A reader YTHDC1 as a critical regulator of telomere homeostasis and senescence evasion in ovarian cancer. YTHDC1 expression was markedly elevated in advanced-stage tumors and correlated with poor patient survival.
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