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Xiaowan Yin on Muck Rack

Xiaowan Yin

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Articles

ZFP36L2 is an interferon β -induced inhibitor that restricts the nuclear export of HIV-1 transcripts

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By Hong Shang, Guoxin Liang, Hailin Pang, Hualu Cui, Xiaowan Yin, Zengwen Yang
| Nature Verified
Abstract Type I interferons restrict HIV-1 replication by inducing antiviral genes, but the full spectrum of their effectors remains incompletely defined. Here we identify ZFP36L2, a nuclear RNA-binding protein, as an IFN-β-induced inhibitor of HIV-1 infection. Silencing of ZFP36L2 impairs IFN-β-mediated HIV-1 inhibition, whereas overexpression of ZFP36L2 suppresses viral replication.
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