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Xiaoxiao Sun

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Articles

Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity

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By Jianfeng Song, Qin Zeng, Xiaoxiao Sun, Limin Xie, Wanyu Hu, Fanqi Wang, Biling Huang, Ying Mei, Dandan Wang, Lan Xie, Xiang Xiao, Wei Liu, Willa A. Hsueh, Xian Li, Tuo Deng, Yayi Jiao, Jingpei Qiu, Yujin Ding, Wuqian Mai
| Nature Verified
Abstract T cells contribute critically to obesity-induced adipose inflammation and insulin resistance, yet the co-stimulatory signals that govern their activation in adipose tissue remain unclear. Here, we systematically profile co-stimulatory molecules in adipocytes and adipose tissue macrophages and identify OX40 ligand (OX40L) as the most robustly upregulated in obesity. OX40L is also elevated in adipocytes from obese humans.
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ResMap: A community resource for systematic mapping of therapy-persistent residual cancer cell dependencies across contexts

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By Kevin Jaksch, Hoang Phan, Mukund Palat Rao, Xiaoxiao Sun, Savitha Gayathri, Karl Kumbier, Heinz Hammerlindl, Erin Ahern, Lani F. Wu, Steven J. Altschuler
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Relapse following targeted therapy remains a central challenge in oncogene-driven cancers.
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Optimization of active support layout for mirrors based on an RBF neural network and a hybrid optimization algorithm

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By Zhixuan Jiang, Zhiguo Li, Xiaoxiao Sun, Xin Wang
| Optica Verified
The optimization of active support layout for mirrors is crucial for ensuring the performance of optical systems. To address the issues of low computational efficiency, long optimization cycles, and susceptibility to local optima in traditional optimization methods, this study proposes a strategy coupling RBF neural networks with hybrid optimization algorithms for optimizing the active support layout of a 450 mm meniscus thin mirror under horizontal working conditions.
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