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Xiaoxiu Tan on Muck Rack

Xiaoxiu Tan

As seen in: Nature, MDPI
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Articles

CROSSTCR: a curated resource for TCR cross-reactivity and off-target risk assessment in precision cancer immunotherapy

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By Wenzhen Li, Wenzhi Li, Pengfei Xin, Yu Pan, Zhenhao Liu, Jinghui Lin, Manman Lu, Xiaoxiu Tan, Jian Huang, Lu Xie, Juping Huang, Qianhe Zhan, Bofu Cao
| Nature Verified
Abstract T cell receptor (TCR) cross-reactivity, the ability of one TCR to recognize multiple peptide–MHC (pMHC) complexes, is essential for immune adaptability but poses major safety risks for TCR-engineered cancer therapies, as molecular mimicry between tumor and self-peptides has led to severe off-target toxicities. We developed CROSSTCR, a manually curated, cross-reactivity-focused database integrating experimentally validated evidence of TCR cross-reactivity.
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PGNneo: A Proteogenomics-Based Neoantigen Prediction Pipeline in Noncoding Regions

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By Linfeng Xu, Xingxing Jian, Jian Ouyang, Xiaoxiu Tan
| MDPI
Abstract : The development of a neoantigen-based personalized vaccine has promise in the hunt for cancer immunotherapy. The challenge in neoantigen vaccine design is the need to rapidly and accurately identify, in patients, those neoantigens with vaccine potential. Evidence shows that neoantigens can be derived from noncoding sequences, but there are few specific tools for identifying neoantigens in noncoding regions.
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