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Xiaoyin Niu

As seen in: Nature, MDPI
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Articles

A pathogenic CD8⁺ T RM –chemokine axis orchestrates liver fibrosis and provides circulating biomarkers during chronic Clonorchis sinensis infection

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By Xinyue Du, Jiashun Li, Xin Wang, Wenyu Wu, Huibo Yan, Chenyun Wu, Yuanyuan Li, Yuwei Gao, Kokouvi Kassegne, Xiangwei Li, Xiaoyin Niu, Samuel C. Wassmer, Youqiong Ye, Banchob Sripa, Guangjie Chen, Zhaojun Wang, Tingjun Zhu, Haibo Yi, Helena Helmby, Menbao Qian
| Nature Verified
Abstract Chronic liver fluke infections represent a major global health burden, driving liver fibrosis and elevating cancer risk, yet the immunological mechanisms linking persistent infection to tissue damage remain poorly defined. Using Clonorchis sinensis, a carcinogenic liver fluke infecting millions worldwide, as a representative model, we map immune responses during chronic infection in mice.
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PRL2 negatively regulates FcεRI mediated activation of mast cells - Cell Death & Disease

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By Xin Guo, Xiaoyin Niu, Zhaojun Wang
| Nature Verified
Abstract Mast cells play a central role in allergic reactions, acting as key effector cells that initiate and amplify the inflammatory response. In this study, we demonstrate that phosphatase of regenerating liver 2 (PRL2) functions as a negative regulator of FcεRI-mediated mast cell activation. In PRL2-deficient myeloid cells, PRL2 conditional knockout mice developed more severe passive systemic anaphylaxis (PSA).
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Immunoregulatory Roles of Osteopontin in Diseases

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By Xiaoyin Niu, Lebei Wang
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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