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Xiaoying Lian on Muck Rack

Xiaoying Lian

As seen in: Nature, MDPI, BioRxiv
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Articles

Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation

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By Shan Hu, Xiaoying Lian, Jinnawat Jongkhumkrong, James D. Sitter, Hao Liu, William E. Cotham, Aaron K. Vannucci, Qian Wang, Öznur Ölmez Nalcıoğlu, Akshani Anjula Wijesooriya, Diqi Yan, Michael Walla
| Nature Verified
Abstract Bioorthogonal reactions enable the study and modulation of biological systems, but achieving precise control over when and where the reactions occur remains challenging. Here we show that cyclopropanol (CPol) can serve as a compact, energy-loaded chemical handle that is stable under physiological conditions, yet can be selectively activated using mild electrochemical stimuli.
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Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads

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By Dan Xue, Mingming Xu, Xiaoying Lian
| BioRxiv
Abstract Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein we report a high-throughput screening platform and the subsequent discovery of a new class of cancer immunogenic chemotherapeutic leads.
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Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model

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By Ethan A. Older, Mary Mitchell Verified, Andrew Campbell, Xiaoying Lian
| BioRxiv
Abstract Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD has not been studied and the underlying molecular mechanisms also remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays the development of colitis.
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