Introduction Insulin autoimmune syndrome (IAS) is a rare disease that is frequently overlooked or misdiagnosed in clinical settings. It was first reported by the Japanese scholar Hirata in 1970; hence, it is also referred to as Hirata’s disease (1). Since then, cases have been identified in numerous countries. Indeed, 795 cases of IAS have been documented worldwide, with the highest prevalence in Japan and China (2) and relatively fewer reports among Caucasian populations (3).
