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Articles by Xin Bin
Dual targeting of ACSS2 and ACLY by a novel inhibitor S8588 suppresses oncogenic lipogenesis and overcomes metabolic compensation in oral squamous cell carcinoma
Abstract Metabolic reprogramming, particularly enhanced lipid anabolism, is a hallmark of oral squamous cell carcinoma (OSCC), yet effective therapies targeting this process remain lacking. Here, we identify concurrent activation of acetyl-CoA synthetase 2 (ACSS2) and ATP-citrate lyase (ACLY) as a cooperative metabolic driver of OSCC progression.
Cellular senescence mediates retinal ganglion cell survival regulation post‐optic nerve crush injury
1 INTRODUCTION Traumatic optic neuropathy refers to an ocular condition with direct or indirect acute injury to the optic nerve (ON) by trauma, resulting in irreversible visual impairment or even blindness.1 Traumatic optic neuropathy can be resulted from explosion, traffic accidents, sports and recreational activities.2, 3 The World Health Organization has estimated that trauma has led to 1.6 million binocular blindness, 2.3 million people with both eyes low vision, and 19 million monocular...
circMTO1/miR‐30c‐5p/SOCS3 axis alleviates oral submucous fibrosis through inhibiting fibroblast-myofibroblast transition
Corresponding Author Ou-Sheng Liu Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China Department of Orthodontics, Xiangya Stomatological Hospital of Central South University, Central South University, Changsha, China Correspondence Zhangui Tang, Department of...
Malignant Hyperthermia: A Killer If Ignored
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