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Articles by Xin Gan
Durvalumab plus anlotinib versus durvalumab alone as maintenance treatment in extensive-stage small-cell lung cancer (DURABLE): a multicenter, randomized, phase II trial and biomarker analysis
Abstract Although first-line immunotherapy plus chemotherapy has made substantial progress in extensive-stage small-cell lung cancer (ES-SCLC), the survival benefit remains limited. DURABLE was a prospective, multicenter, open-label, randomized, phase II trial (NCT04985851) that evaluated the efficacy and safety of durvalumab plus anlotinib as consolidative maintenance therapy following first-line durvalumab plus platinum-etoposide chemotherapy in ES-SCLC.
Genkwanin mitigates renal fibrosis by reprogramming profibrotic signaling and restoring TFEB-mediated autophagy
Abstract Background: Renal fibrosis is a common pathological outcome of chronic kidney disease and is characterized by persistent profibrotic signaling and impaired cellular homeostasis. Genkwanin (GAK), a natural flavonoid compound, has shown anti-inflammatory and antioxidant activities in several disease models. However, its role in renal fibrosis remains unclear.
Frontiers | Dynamic trajectories of the triglyceride-glucose index link to all-cause hospital mortality in patients with hypertension and kidney failure: a multicenter study
1 Introduction Chronic kidney disease (CKD) is a global health challenge affecting over 850 million individuals worldwide (1, 2), with 1.2 million deaths attributed to the condition in 2017, and projections indicate this number will rise to 2.2 million by 2040 under best-case scenarios and potentially reach 4.0 million annually in worst-case scenarios (3). Hypertension, a key risk factor for cardiovascular disease and kidney failure (KF), coexists in about 50% of CKD patients (4, 5).
Applications of Hydrogels in Osteoarthritis Treatment
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Tumor-Derived Sarcopenia Factors Are Diverse in Different Tumor Types: A Pan-Cancer Analysis
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The Role of NCS1 in Immunotherapy and Prognosis of Human Cancer
1. Introduction The main treatment for advanced cancer is immunotherapy, but there are many patients who do not respond to it, limiting its clinical applicability. Therefore, the study of new immune markers and understanding the mechanisms of immune marker resistance is a research priority [1]. Intracellular calcium signaling plays a role in regulating cancer progression.
Nanostripe-Confined Catalyst Formation for Uniform Growth of Ultrathin Silicon Nanowires
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Ultrahigh rate sodium ion storage with nitrogen-doped expanded graphite oxide in ether-based electrolyte
Exploring anode materials with excellent rate performance and high initial coulombic efficiency (ICE) is crucial for lithium/sodium-ion batteries (LIBs/SIBs). However, it is still very challenging to achieve this goal in a cost-effective way, particularly for SIBs. Herein, graphite oxide, was treated in ammonia atmosphere for a balance between the oxygen- and nitrogen-contained functional groups and yielded nitrogen-doped expanded graphite oxide (NEGO).
Ultrahigh rate sodium ion storage with nitrogen-doped expanded graphite oxide in ether-based electrolyte
Exploring anode materials with excellent rate performance and high initial coulombic efficiency (ICE) is crucial for ithium/sodium-ion batteries (LIBs/SIBs). However, it is still very challenging to achieve this goal in a cost-effective way, especially for SIB. Here, graphite oxide, a mature industrial product, was treated in ammonia atmosphere for a balance between the oxygen- and nitrogen-contained functional groups and formed nitrogen-doped expanded graphite oxide (NEGO).
Polymer-Coated Graphene Films as Anti-Reflective Transparent Electrodes for Schottky Junction Solar Cells
Traditional fabrication of graphene-based devices requires polymer-assisted transfer of graphene and removal procedure of polymer coatings. Here, we propose to turn this process on its head and demonstrate a novel strategy of polymer-coated graphene as an optically antireflective and transparent electrode used in graphene/silicon (G/Si) solar cell. No additional polymer removal and antireflection coatings (e.g. TiO colloid) are needed in our strategy.
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