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Articles by Xin Lan
Identification of a unique Env protein mutation associated with ALV-J-induced hemangioma
Abstract ALV-J is a retrovirus which can induce diverse tumors in chickens. In this study, ALV-J was identified as the causative agent of both hemangioma and lymphocyte-like tumors in Chinese indigenous layer hens. Microscopic analysis revealed significant vascular endothelial cell hyperplasia across multiple tissues. Viral isolation and sequencing identified unique insertion mutations in the env gene and the 3'UTR.
Amazon carbon emissions driven by human actions amplified by droughts
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Abstract The Amazon carbon sink is weakening as deforestation1,2,3,4,5, rising tree mortality6,7,8 and climate change disrupt the climatic conditions that sustain a humid tropical forest9,10,11. Forest loss reduces precipitation, increases temperatures and lengthens the dry season, driving higher carbon emissions1,2,3,4,11,12. Climate stress is stronger in more deforested regions, rendering forests progressively more flammable1,9,13.
By Luciana V. Gatti, Camilla L. Cunha, Juan Blas, A. Scott Denning, Mariane S. Reis, Luciano Marani, Egidio Arai, Cassiano Gustavo Messias, Dhemerson E. Conciani, Vanúcia Schumacher, José A. Marengo, Luciana Soler, Claudio Almeida, Carlos Nobre, Sergio M. Corrêa, Elliott Campbell, Jennifer Johnson, Joseph Berry, Alber Sanchez, Vagner L. Camilotti, Filipe Lopes, Xin Lan, Gabrielle Pétron, Guilherme Machado, Kleber P. Naccarato, Ane A. C. Alencar, Lucas Gatti Domingues, Caio S. C. Correia, Raiane A. L. Neves, Francine M. da Silva, Christiane Silvestrini, Marcio Malacarne
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Nature
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Cost-effectiveness analysis of pembrolizumab plus trastuzumab and chemotherapy as first-line treatment for HER2-positive gastric or gastroesophageal junction adenocarcinoma
Abstract Objectives: The final analysis of KEYNOTE-811 demonstrated that pembrolizumab plus trastuzumab and chemotherapy significantly improved both overall survival (OS) and progression-free survival (PFS) compared to trastuzumab plus chemotherapy alone.
Definition and core characteristics of scarce medicinal resources of Traditional Chinese Medicine and ethnic medicine in Xinjiang, China
Abstract Scarce medicinal resources constitute the natural resources of Traditional Chinese Medicine and ethnic minority medicine (TCM-EM). However, the vague understanding of scarce (shortage) medicinal resources and scarce (shortage) medicinal materials makes it impossible to predict scarce resources and fails to effectively meet the demands in cultivation and medical treatment.
Isotopic constraints in methane inversions reveal larger trends in wetland emissions with improved linkage to terrestrial water storage
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Abstract Accurately separating the contributions of different sources to recent atmospheric methane (CH4) growth is crucial for better quantifying the present and future responses of CH4 emissions to changing climate and anthropogenic activity.
By Youmi Oh, Lori Bruhwiler, Xin Lan, Santanu Halder, Ben Riddell-Young, Sourish Basu, John Miller, Sylvia Englund Michel, Arlyn Andrews, Sebastien Biraud, Elena Kozlova, Licheng Liu, Martin Steinbacher, Taku Umezawa, Irène Xueref-Remy, Giulia Zazzeri, Ken Schuldt, Tatiana Di lorio, Elise-Andree Guerette, Simonetta Montaguti, Shinji Morimoto
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Nature
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Experiences and coping with kinesiophobia in patients with post-stroke limb dysfunction: a qualitative study
Abstract Purpose Kinesiophobia is a major barrier to post-stroke rehabilitation, yet lived experience and support needs of stroke survivors with limb dysfunction remain poorly understood. This study explored the experiences, coping responses, and support needs related to kinesiophobia in this population. Materials and Methods : A phenomenological qualitative design was adopted. Fifteen stroke survivors with clinically significant kinesiophobia were recruited using purposive sampling.
Reconstitution of protein arginylation pathways in bacteria for robust identification and quantification
Abstract ATE1 is a conserved enzyme that catalyzes the covalent addition of arginine to proteins bearing N-terminal or mid-chain Asp and Glu residues. N-terminal (Nt) arginylation can also occur on Cys, Asn, and Gln following enzymatic conversion, often marking proteins for degradation. Essential for development, this pathway contributes to protein quality control and stress responses.
Incorporating methane isotopologues alters tropical and subtropical methane emission estimates
Abstract Annual increases in atmospheric methane have reached record highs over the past five years, yet the underlying processes and regional sources remain uncertain. Here we quantify the average 2019-2021 global methane budget using Bayesian 4D-Var inversions that assimilate satellite methane retrievals and in-situ δ13C-CH4 and δD-CH4 measurements. The methane-isotopic inversion yields total emissions of 623 [585–643] Tg/y, slightly higher than the methane-only inversion.
Mapping the mutational landscape of an avian retrovirus envelope protein across its evolutionary trajectory
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Xu M, Liu Y, Lan X, Wang Z, Qian K, Shao H, et al. (2026) Mapping the mutational landscape of an avian retrovirus envelope protein across its evolutionary trajectory. PLoS Pathog 22(3): e1014110. https://doi.org/10.1371/journal.ppat.1014110 Editor: Marcelo A.
Biophysical factors and management practices are key to shaping forest resilience - Nature Communications
Abstract Forest management influences key ecosystem services essential for societal well-being. However, how these human management activities affect forest resilience under different environmental conditions remains poorly understood. This study investigates how different forest management practices interact with biophysical factors and explores their joint effect on forest resilience globally during 2001–2015.
Emerging climate impact on carbon sinks in a consolidated carbon budget
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Abstract Despite the adoption of the Paris Agreement 10 years ago, carbon dioxide (CO2) emissions from burning fossil fuels continue to increase, pushing atmospheric CO2 levels to 423 ppm in 2024 and driving human-induced warming to 1.36 °C, within years of breaching the 1.5 °C limit1,2. Accurate reporting of anthropogenic and natural CO2 sources and sinks is a prerequisite to tracking the effectiveness of climate policy and detecting carbon-sink responses to climate change.
By Pierre Friedlingstein, Corinne Le Quéré, Michael O’Sullivan, Judith Hauck, Peter Landschützer, Ingrid T. Luijkx, Hongmei Li, Clemens Schwingshackl, Julia Pongratz, Pierre Regnier, Robbie M Andrew, Dorothee Bakker, Josep G. Canadell, Philippe Ciais, Thomas Gasser, Matthew Jones, Xin Lan, Eric Morgan, Are Olsen, GLEN Peters, Wouter Peters, Stephen Sitch, Hanqin Tian, Auke van der Woude
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Nature
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Effect of ultrafiltration mode on postoperative cognitive function in | TCRM
Back to Journals » Therapeutics and Clinical Risk Management » Volume 21 Authors Lan X, Tang S, Lu J, Tang G, Shao Y, Zhu Z , Zhou K, Xiong X, Chen D, Shi J Received 25 September 2025 Accepted for publication 11 December 2025 Published 23 December 2025 Volume 2025:21 Pages 1807—1819 DOI https://doi.org/10.2147/TCRM.S570006 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Sandeep Ajoy Saha Xin Lan,1,2,* Sijie...
Acute mental health benefits of urban nature - Nature Cities
Abstract Mental disorders are more prevalent in cities, yet the global impact of urban nature on mental health remains insufficiently understood. Here we address this gap by systematically reviewing 449 peer-reviewed studies and conducting a meta-analysis of 78 field-based experiments to quantify the effects of various urban nature types on 12 mental health outcomes.
Effect of Ciprofol on postoperative cognitive function in patients und
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Lu J, Shi Y, Lan X, Tang G, Shao Y, Chen C, Xiong X, Chen D, Shi J Received 28 May 2025 Accepted for publication 23 August 2025 Published 29 August 2025 Volume 2025:19 Pages 7541—7552 DOI https://doi.org/10.2147/DDDT.S536225 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Anastasios Lymperopoulos Jun Lu,1,* Yewei Shi,1,* Xin...
FABLE: A Localized, Targeted Adversarial Attack on Weather Forecasting Models
Work on one of the world's most important websites and make an impact on open science.
Trends in the seasonal amplitude of atmospheric methane - Nature
Abstract Methane is an important greenhouse gas1 and its atmospheric concentration has almost tripled since pre-industrial times2,3,4. Atmospheric methane mixing ratios vary seasonally, with the seasonal cycle amplitude (SCA) having decreased in northern high latitudes and increased in the subtropics and tropics since the 1980s5,6. These opposing SCA trends can help understanding of long-term changes in the global methane budget, as methane emissions and sinks have opposing effects on the SCA5.
The Role of Wolfiporia cocos (F. A. Wolf) Ryvarden and Gilb. Polysaccharides in Regulating the Gut Microbiota and Its Health Benefits
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Comparative Analysis of YOLO Series Algorithms for UAV-Based Highway Distress Inspection: Performance and Application Insights
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Phytochemical Compositions and Antioxidant Activities of Different Cultivars of Prunus salicina Lindl. in Southern China
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , , and , “Phytochemicals Accumulation in Sanhua Plum (Prunus salicina L.) During Fruit Development and Their Potential use as Antioxidants,” Journal of Agricultural and Food Chemistry 67 (2019): 2459–2466. 2, , , , and , “Changes in the Primary Metabolites of ‘Fengtang’ Plums During Storage Detected by Widely Targeted Metabolomics,” Foods 11 (2022): 2830.
An Improved Real-Time Detection Transformer Model for the Intelligent Survey of Traffic Safety Facilities
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Removal of Phosphate from Water by Iron/Calcium Oxide-Modified Biochar: Removal Mechanisms and Adsorption Modeling
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Short-Peptide-Modified Copper Nanoclusters as a Fluorescent Probe for the Specific Detection of Ascorbic Acid
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy
Editor’s summary T cell immunotherapies have been successful in treating some intractable cancers, but there are limitations caused by the inability of T cells to persist after prolonged stimulation. Kang et al. undertook a reverse-translation approach to investigate the molecular mechanisms regulating the durability of T cell responsiveness to checkpoint blockade immunotherapy (see the Perspective by Tsui and Kallies).
Water Niche Characteristics of Subalpine Shrub in Eastern Qilian Mountains, China
References , , , et al. 2023. “Isotopic Evidence for an Intensified Hydrological Cycle in the Indian Sector of the Southern Ocean.” Nature Communications 14, no. 1: 2763. https://doi.org/10.1038/s41467-023-38425-5 , and . 2002. “Constraints on Future Changes in Climate and the Hydrologic Cycle.” Nature 419, no. 6903: 224–232. https://doi.org/10.1038/nature01092 , , , et al. 2020. “Depth Distribution of Soil Water Sourced by Plants at the Global Scale: A new Direct Inference Approach.” Ecohydrology 13, no.
Characterization and Pathogenicity of a Porcine Reproductive and Respiratory Syndrome Virus Strain with Strong Homology to a HP‐PRRSV Vaccine Strain in the Field
1. Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, single-stranded, positive-sense RNA virus of the genus Porartevirus of the family Arteriviridae of the order Nidovirales [1, 2]. Since it emerged in the United States in 1987 [3] and Europe in 1991 [4], PRRSV has rapidly spread to swine-producing countries and has become a devastating disease of pigs worldwide [4, 5, 6, 7, 8].
Morin against neuropathic pain
Yi Shao,* Yunfu Chen,* Xin Lan, Jun Lu, Guangling Tang, Sijie Tang, Ruixue Zhai, Chao Chen, Xinglong Xiong, Jing Shi Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People’s Republic of China *These authors contributed equally to this work Correspondence: Jing Shi, Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Beijing Road, Guiyi Street, Yunyan District, Guiyang, Guizhou,...
Molecular Dynamics Simulation of the Cu3Sn/Cu Interfacial Diffusion Mechanism under Electrothermal Coupling
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Water | Free Full-Text | Spatial and Temporal Variation Characteristics of Stable Isotopes in Precipitation and Their Relationships with Meteorological Factors in the Shiyang River Basin in China
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The HLA advantage: Why COVID-19 benched you but not your co-worker
Editors' Choice FOCIS HIGHLIGHTS It is estimated that at least 1 in 5 people infected with COVID-19 are asymptomatic. Despite the central role of human leukocyte antigen (HLA) variation in susceptibility to viral infection, relatively little is understood about its role in conferring protection against symptomatic COVID-19 disease. To shed light on this important question, Augusto et al.
Everything everywhere all at once
Editors' Choice FOCIS HIGHLIGHTS Immunotherapy harnessing tumor-infiltrating lymphocytes (TILs) is advancing cures for patients with otherwise-intractable solid tumors. Antibody-targeted endogenous CD8+ T cells and ex vivo engineered autologous chimeric antigen receptor T (CAR-T) or tumor specific antigen (TSA)–specific CD8+ T cells (TCR-T) are potent immunotherapies. However, immune escape when tumors downregulate class I or TSA expression is a key challenge to durable responses.
Sinking while you swim: A dual role for CCR7 in leukocyte migration
Published In Science Immunology Volume 8 | Issue 87 September 2023 Article versions Permissions Request permissions for this article. Acknowledgments Funding: This work was funded by core grant A24450 from Cancer Research UK, Programme Grant MR/X000702/1 from the Medical Research Council (MRC), and Wellcome Investigator grant 221786/Z/20/Z to R.I. Author contributions: H.D., E.M., and R.I. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.
Cellular and molecular waypoints along the path of T cell exhaustion
Published In Science Immunology Volume 8 | Issue 87 September 2023 Article versions Submission history Received: 20 December 2022 Accepted: 9 August 2023 Permissions Request permissions for this article. Acknowledgments We thank members of Youngblood and Zebley laboratories for constructive feedback and editing. We apologize for any related studies not cited in this review due to the reference limit.
Everything everywhere all at once
Editors' Choice FOCIS HIGHLIGHTS Immunotherapy harnessing tumor-infiltrating lymphocytes (TILs) is advancing cures for patients with otherwise-intractable solid tumors. Antibody-targeted endogenous CD8+ T cells and ex vivo engineered autologous chimeric antigen receptor T (CAR-T) or tumor specific antigen (TSA)–specific CD8+ T cells (TCR-T) are potent immunotherapies. However, immune escape when tumors downregulate class I or TSA expression is a key challenge to durable responses.
Sinking while you swim: A dual role for CCR7 in leukocyte migration
Published In Science Immunology Volume 8 | Issue 87 September 2023 Article versions Permissions Request permissions for this article. Acknowledgments Funding: This work was funded by core grant A24450 from Cancer Research UK, Programme Grant MR/X000702/1 from the Medical Research Council (MRC), and Wellcome Investigator grant 221786/Z/20/Z to R.I. Author contributions: H.D., E.M., and R.I. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.
CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
Published In Science Immunology Volume 8 | Issue 87 September 2023 Article versions Submission history Received: 11 May 2022 Accepted: 9 August 2023 Permissions Request permissions for this article. Acknowledgments We thank I. de Vries and the Scientific Service Units (Life Sciences, Bioimaging, Nanofabrication, Preclinical and Miba Machine Shop) of the Institute of Science and Technology Austria for excellent support, as well as all the rotation students assisting in the laboratory work (B.
Cellular and molecular waypoints along the path of T cell exhaustion
Published In Science Immunology Volume 8 | Issue 87 September 2023 Article versions Submission history Received: 20 December 2022 Accepted: 9 August 2023 Permissions Request permissions for this article. Acknowledgments We thank members of Youngblood and Zebley laboratories for constructive feedback and editing. We apologize for any related studies not cited in this review due to the reference limit.
Does it matter how much the United States reduces its carbon dioxide emissions if China doesn’t do the same?
Please note: Due to storm impacts on systems at NOAA's National Centers for Environmental Information in Asheville, NC, certain data services may be temporarily unavailable or experiencing issues. We apologize for any inconvenience. Read more > Yes, it matters. Observed and anticipated increases in greenhouse gas emissions from China and other countries don’t let Americans off the hook for reducing emissions.
Field Testing and Numerical Simulation of the Effectiveness of Trench Isolation for Reducing Vibration due to Dynamic Compaction
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 1, 1,*, 1, 2, 2 and 1 1 College of Civil Engineering, Tongji University, Shanghai 200092, China 2 Anhui Changjiang LNG Co., Ltd., Wuhu 241000, China * Author to whom correspondence should be addressed. Appl. Sci.
CNTR-YOLO: Improved YOLOv5 Based on ConvNext and Transformer for Aircraft Detection in Remote Sensing Images
Abstract : Aircraft detection in remote sensing images is an important branch of target detection due to the military value of aircraft. However, the diverse categories of aircraft and the intricate background of remote sensing images often lead to insufficient detection accuracy. Here, we present the CNTR-YOLO algorithm based on YOLOv5 as a solution to this issue. The CNTR-YOLO algorithm improves detection accuracy through three primary strategies.
Land‐Use Intensity Reversed the Role of Cropland in Ecological Restoration Over the World's Most Severe Soil Erosion Region
2.3.4 C Factor Vegetation cover and land cover protect soil primarily by trapping rainfall, increasing infiltration, and slowing runoff rates, thereby reducing soil erosion. Vegetation cover, vegetation type and management mode are different and have different effects on soil erosion. In the RUSLE model, the C factor is used to reflect the influence of vegetation cover and management measures on soil erosion.
A Fast Circle Detection Algorithm Based on Circular Arc Feature Screening
3. Experiments and Results Analysis In this section, we compared the algorithm proposed in this paper with five other algorithms. The first is the RHT algorithm proposed by Xu et al. [10]. The second is the RCD algorithm proposed by Chen et al. [12]. The third is a difference region sampling algorithm proposed by Jiang [15]. The fourth is an improved sampling algorithm proposed by Wang [14]. The fifth is the CACD algorithm proposed by Yao et al.
Publisher Correction: Atmospheric observations suggest methane emissions in north-eastern China growing with natural gas use - Scientific Reports
Correction to: Scientific Reports https://doi.org/10.1038/s41598-022-19462-4, published online 17 November 2022 The original version of this Article contained an error in the upper panel of Figure 4, where the Total CH4 emission was inadvertently shown in three lines instead of in a solid line with the uncertainty displayed in orange shadow. The original Figure 4 and accompanying legend appear below.
Wetland emission and atmospheric sink changes explain methane growth in 2020 - Nature
Abstract Atmospheric methane growth reached an exceptionally high rate of 15.1 ± 0.4 parts per billion per year in 2020 despite a probable decrease in anthropogenic methane emissions during COVID-19 lockdowns1. Here we quantify changes in methane sources and in its atmospheric sink in 2020 compared with 2019.
BATF targets T cell exhaustion for termination - Nature Immunology
New reports provide further insight into the role of the transcription factor BATF in pivoting the differentiation of CD8+ T cells away from T cell exhaustion and facilitating the transition of these cells into potent effectors. Recent work has demonstrated that the pool of exhausted T cells is heterogeneous, with several distinct subtypes of T cells represented in various developmental states.
Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process
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Investigation of Combustion Enhancement by Ozone in a Constant-Volume Combustion Bomb
RETURN TO ARTICLES ASAPPREVArticleNEXT Shaobo Ji* Hao Wang Hao Wang College of Energy and Power Engineering, Shandong University, Jinan 250061, Shandong Province, China Minglei Shu Minglei Shu Qilu University of Technology (Shandong Academy of Sciences), Shandong Computer Science Center (National Supercomputer Center in Jinan), Shandong Artificial Intelligence Institute, Jinan 250353, Shandong, China Guohong Tian Guohong Tian Department of Mechanical Engineering Sciences, University of...
Long‐Term Measurements Show Little Evidence for Large Increases in Total U.S. Methane Emissions over the Past Decade
Research Letter Long‐Term Measurements Show Little Evidence for Large Increases in Total U.S. Methane Emissions over the Past Decade Xin Lan Corresponding Author E-mail address: xin.lan@noaa.gov https://orcid.org/0000-0001-6327-6950 National Oceanic and Atmospheric Administration, Earth System Research Laboratory, Boulder, Colorado, USA University of Colorado, Cooperative Institute for Research in Environmental Sciences, Boulder, Colorado, USA Search for more papers by this author This...
Direct Detection of the Open-Shell Singlet Phenyloxenium Ion: An Atom-Centered Diradical Reacts as an Electrophile
A new photoprecursor to the phenyloxenium ion, 4-methoxyphenoxypyridinium tetrafluoroborate, was investigated using trapping studies, product analysis, computational investigations, and laser flash photolysis experiments ranging from the femtosecond to the millisecond time scale.
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