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Xin Xue

As seen in: Nature, Wiley Online Library, Journal of Neurology, Neurosurgery and Psychiatry, MDPI, Taylor & Francis Online, ACS Publications, Alzheimer's Research and Therapy, Royal Society of Chemistry, Canadian Journal of Infectious Diseases & Medical Microbiology, Journal of Advanced Transportation and
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Articles

Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson’s disease

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By Yi-Yan Sun, Hua-Mei Lin, Jie Ma, Zhi-Jie Xu, Xin Xue, Juan-Juan Lu, Jia-Jia Wu, Xu-Yun Hua, Chuan-Tao Zuo, Jian-Guang Xu
| Nature Verified
Abstract Motor impairment in Parkinson’s disease (PD) is classically attributed to striatal dopaminergic degeneration, yet dopamine loss alone does not fully explain symptom severity, suggesting a key role for circuit-level mechanisms. The cortico–basal ganglia–thalamo–cortical (CBGTC) system is central to dopaminergic motor modulation, but whether dysfunction within individualized CBGTC circuits mediates motor severity across disease stages remains unclear.
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A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer

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By Xin Xue, Xiao Chen, Yitian Jiang
| Wiley Online Library Verified
X.Xue, X.Chen, Y.Jiang, et al., “A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer,” Medicinal Research Reviews0 (2026): 1-44, https://doi.org/10.1002/med.70057. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing is not applicable to this article as no new data sets were generated or analyzed during the current study.
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Explainable machine learning prediction of tracheostomy after craniotomy for supratentorial intracerebral hemorrhage - Scientific Reports

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By Xin Xue, huanhuan yu, Di Tian, Yuting Wang, Qi Liu, Quancai Li, Feiyu Qiao, Yanrui Cai
| Nature Verified
Abstract Accurate prediction of tracheostomy after craniotomy for supratentorial intracerebral hemorrhage (sICH) remains challenging. This study aimed to develop, externally validate, and interpret a machine learning model for individualized risk prediction. A retrospective multicenter cohort was constructed, including 738 patients from Weifang People’s Hospital and 186 from Weifang Hospital of Traditional Chinese Medicine who underwent craniotomy between January 2017 and December 2024.
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