Xingli Gu

1 Introduction Erectile dysfunction (ED) is a common disease in andrology, which brings about not only an unsatisfactory sexual experience but also mental distress. The prevalence of ED increased from 6% to 64% with age [1], and it was predicted that the ED-affected population worldwide would increase to about 322 million by 2025 [2]. In the treatment of ED, phosphodiesterase 5 (PDE5) inhibitors have become the first-line choice [3].

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What is the current knowledge on the topic? ○ Aripiprazole, a second-generation antipsychotic, is a cornerstone for schizophrenia treatment. ○ Traditional formulations like tablets face challenges with medication adherence. What question did this study address? ○ This study addressed the bioequivalence, pharmacokinetic properties, and safety of aripiprazole oral soluble films (OSF) compared to orally disintegrating tablets (ODT) in healthy Chinese participants.