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Xingqu Chen on Muck Rack

Xingqu Chen

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Articles

Metabolomic profiling reveals persistent metabolic alterations and selective working memory deficits following neonatal anesthesia in rats

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By Ling Qiu, Deshui Yu, Xiaobin Wang, Xingqu Chen
| Nature Verified
Abstract Preclinical studies have established that common pediatric anesthetics such as sevoflurane and propofol can induce neurotoxicity, yet their molecular mechanisms remain incompletely elucidated. This study combined LC-MS-based metabolomics with caspase-3 and cleaved caspase-3 immunoblotting, Y-maze, and Morris water maze testing to investigate metabolic alterations linked to anesthesia-induced neurotoxicity in neonatal Sprague-Dawley rats.
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