Xingsen Chen

Abstract The energy-momentum (E-k) dispersion of quasiparticles constitutes a fundamental concept in condensed matter systems. The ability to modify the E-k dispersion, exemplified by supercurrent-induced Doppler shifts of Bogoliubov quasiparticle spectra in superconductors, enables manipulation of various emergent quantum properties. However, investigations into the supercurrent effect on superconductors intertwined with charge orders remain scarce.

OSA is a founder of Agragene, Inc. and Synvect, Inc. with equity interest. The terms of this arrangement have been reviewed and approved by the University of California San Diego, in accordance with its conflict of interest policies. All other authors declare no competing interests. Funder Information Declared Defense Advanced Research Projects Agency, https://ror.org/02caytj08, HR0011-17-2-0047 National Institutes of Health, https://ror.org/01cwqze88, R35GM153242, 5T32GM133351-02

Abstract CRISPR-Cas9 gene drives (CCGDs) are powerful tools for genetic control of wild populations, useful for eradication of disease vectors, conservation of endangered species and other applications. However, Cas9 alone and in a complex with gRNA can cause double-stranded DNA breaks at off-target sites, which could increase the mutational load and lead to loss of heterozygosity (LOH).