Xingyin Liu

Keywords autism spectrum disorder multi-omics neuroimaging metabolome gut microbiota Introduction The etiology of autism spectrum disorder (ASD) is highly heterogeneous, involving a complex interplay of genetic predispositions, environmental factors, and early developmental processes.1,2 While extensive research has focused on identifying specific genetic variants3 and brain abnormalities,4 a holistic understanding of ASD pathophysiology necessitates a broader perspective that integrates...

Adults aged 18 years and older identified as candidates for surgical intervention for colorectal cancer were recruited voluntarily from the Third Affiliated Hospital of Nanjing Medical University, located in Nanjing, China. Exclusion criteria encompassed recent administration of chemotherapy, radiation therapy, or antibiotics within the 14 days preceding enrollment, leading to the inclusion of 24 subjects (Additional file 2: Table S1).

Abstract Functional profiling on whole-metagenome shotgun sequencing (WMS) has made great contribution to the development of our understanding in microbe-host interactions. In this work, we revealed that severe microbial functional information loss of current functional profiling methods existed at both taxon-level and community-level.