Xinlang Liu on Muck Rack

Xinlang Liu

As seen in: Nature
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Articles

Restoration of axon initial segment plasticity via chemogenetic activation rescues autism-related behaviors

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By Yoshinori Otani, Xiaowei Zhu, Kohei Koga, Ryo Kawabata, Hisao Miyajima, Toru Takumi, Masashi Fujitani, Xinlang Liu
| Nature
Abstract Autism spectrum disorder (ASD) presents a major clinical challenge, necessitating the identification of novel therapeutic targets rooted in its underlying pathophysiology. The axon initial segment (AIS) is the critical site for action potential initiation and a hub for homeostatic plasticity; however, its involvement in ASD remains poorly defined.
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