Xinpu Yang

Abstract The development and function of B lymphocytes require the precise integration of signaling, transcriptional networks, and metabolic programs. While interferon (IFN)-inducible proteins can bridge innate and adaptive immunity, their roles in B cells remain poorly defined. Here, we identified RNF213, a giant IFN-inducible RING finger E3 ligase, as a key orchestrator of B-cell biology.

1 Introduction Genetic diseases arise from DNA abnormalities mainly in the nuclear or mitochondrial genome, which disrupt cellular functions and cause a range of health concerns.[1] These conditions can be inherited from parents or spontaneously arise due to individual DNA changes, affecting different body regions and organs.[1, 2] Current methods of intervention for addressing genetic disorders include medications, physiotherapy, and supportive measures.