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Articles by Xinzheng Guo
IJMS | Free Full-Text | Comprehensive Analysis of Photoreceptor Outer Segments: Flow Cytometry Characterization and Stress-Driven Impact on Retinal Pigment Epithelium Phagocytosis
1. Introduction Age-related macular degeneration (AMD) affects 200 million people worldwide and is a condition that causes damage to the central region of the retina, leading to irreversible vision loss and blindness [1,2]. The pathophysiology of AMD is complex and involves various cellular and molecular processes, during which retinal pigment epithelium (RPE) functions are impaired [3].
Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis
1Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)/Universidad Católica de Córdoba (UCC) & Fundación para el Progreso de la Medicina, Córdoba, Argentina 2Facultad de Ingeniería, Universidad Católica de Córdoba (UCC), Córdoba, Argentina 3Laboratorio de Inmuno Oncologia Traslacional, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y...
Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy
Introduction Triple-negative breast cancer (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for approximately 25-30% of all breast cancers and exhibits poor prognosis and strong invasiveness (1) As the standard treatment strategy for early-stage TNBC, neoadjuvant chemotherapy (NAC) not only provides opportunities for breast conservation and sparing axillary lymph node dissection but also...
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Ahn S. Olive M. Aggarwal S. Krylov D. Ginty D.D. Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 1998; 18: 967-977 Almasieh M. Levin L.A. Neuroprotection in Glaucoma: Animal Models and Clinical Trials. Annu. Rev. Vis. Sci. 2017; 3: 91-120 Ashpole N.M. Hudmon A. Excitotoxic neuroprotection and vulnerability with CaMKII inhibition. Mol. Cell. Neurosci. 2011; 46: 720-730 Ashpole N.M. Song W. Brustovetsky T.
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