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Xinzu Chen

As seen in: Nature, Dialnet - Universidad de La Rioja
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Articles

ARID1A loss drives gastric signet ring cell carcinoma by regulating mucin production and secretion

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By Hongyu Liu, Ailing Zhong, Zhenghao Lu, Limin Gao, Mengsha Zhang, Jiaxin Li, Yingjie Wang, Yiyun Wang, Lanxin Zhang, Jiabo Zhang, Xiangyu Pan, Xuelan Chen, Jingyao Chen, Siyu He, Xinyuan Wang, Xudong Wan, Xintong Deng, Tingfa Peng, Jian Wang, Jiajia Du, Kun Yang, Kai Liu, Xinzu Chen, Xiaolong Chen, Zhe Feng, Baohong Wu, Jing Xu, Linyong Zhao, Weihan Zhang, Shengyong Yang, Yuan Wang, LU CHEN, Zhihong Xue, Chengjian Zhao, Lunzhi Dai, Feifei Na, Jiankun Hu, Yu Chi Liu, Chong Chen
| Nature Verified
Abstract Signet ring cell carcinoma (SRCC) is a lethal malignancy with distinct histologic features, characterized by accumulated mucins in the cytoplasm which compress nuclei. Gastric SRCC is the most common SRCC whose incidence is increasing in recent years. The molecular mechanisms underlying the histopathology remain poorly understood.
Open in Who Shared Issue with article?

DC vaccine enhances CAR-T cell antitumor activity by overcoming T cell exhaustion and promoting T cell infiltration in solid tumors

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By Miaomiao Zhang, Yuanyuan Wang, fan zhang, Xinzu Chen
| Dialnet - Universidad de La Rioja
Objective Great success has been achieved in CAR-T cell immunotherapy in the treatment of hematological tumors. However, it is particularly difficult in solid tumors, because CAR-T is difficult to enter interior and exert long-term stable immune effects. Dendritic cells (DCs) can not only present tumor antigens but also promote the infiltration of T cells. Therefore, CAR-T cells with the help of DC vaccines are a reliable approach to treat solid tumors.
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